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QuickView for SLC9A8 (gene)


Gene Symbol:
SLC9A8 Homo sapiens Homo sapiens
Full name:
solute carrier family 9 member A8
Synonyms:
NHE-8, NHE8, sodium/hydrogen exchanger 8, Na(+)/H(+) exchanger 8, solute carrier family 9 (sodium/hydrogen exchanger), solute carrier family 9 (sodium/hydrogen exchanger), member 8, solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
Genomic Location:
Chr 20: 47862657-47942179
Description:
Sodium-hydrogen exchangers (NHEs), such as SLC9A8, are integral transmembrane proteins that exchange extracellular Na+ for intracellular H+. NHEs have multiple functions, including intracellular pH homeostasis, cell volume regulation, and electroneutral NaCl absorption in epithelia (Xu et al., 2008 [PubMed 18209477]).
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Macaca mulatta Gallus gallus Pan troglodytes Danio rerio Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 20
20q13.13





GO Molecular Function

monovalent cation:proton antiporter activity | proton transmembrane transporter activity | transmembrane transporter activity | potassium:proton antiporter activity | cation transmembrane transporter activity | potassium ion antiporter activity | antiporter activity | active transmembrane transporter activity | transporter activity | ion transmembrane transporter activity | cation:cation antiporter activity | metal ion transmembrane transporter activity | potassium ion transmembrane transporter activity | sodium:proton antiporter activity | sodium ion transmembrane transporter activity | secondary active transmembrane transporter activity | solute:proton antiporter activity | inorganic cation transmembrane transporter activity | monovalent inorganic cation transmembrane transporter activity

GO Biological Process

monovalent cation:proton antiporter activity | establishment of localization | proton transmembrane transporter activity | cellular chemical homeostasis | cellular process | proton transmembrane transport | localization | cellular homeostasis | metal ion transport | transmembrane transporter activity | potassium:proton antiporter activity | ion transmembrane transport | sodium ion transport | cation transmembrane transporter activity | potassium ion antiporter activity | cellular ion homeostasis | monovalent inorganic cation transport | antiporter activity | active transmembrane transporter activity | cellular potassium ion transport | ion transmembrane transporter activity | potassium ion transport | cation:cation antiporter activity | cation homeostasis | cellular cation homeostasis | regulation of intracellular pH | homeostatic process | cation transmembrane transport | regulation of pH | import into cell | metal ion transmembrane transporter activity | potassium ion transmembrane transporter activity | sodium:proton antiporter activity | chemical homeostasis | sodium ion import across plasma membrane | sodium ion transmembrane transport | ion homeostasis | sodium ion transmembrane transporter activity | inorganic cation transmembrane transport | secondary active transmembrane transporter activity | solute:proton antiporter activity | regulation of cellular pH | transmembrane transport | inorganic cation transmembrane transporter activity | cellular monovalent inorganic cation homeostasis | monovalent inorganic cation transmembrane transporter activity | cation transport | inorganic cation import across plasma membrane | potassium ion transmembrane transport | ion transport

GO Cellular Component

integral component of membrane | intracellular membrane-bounded organelle | organelle membrane | cell | intrinsic component of membrane | cytoplasm | intracellular organelle | Golgi apparatus | endomembrane system | plasma membrane | Golgi membrane | membrane-bounded organelle | organelle | cell periphery | intracellular | membrane