QuickView for SMAD2 (gene)

Gene Symbol:

SMAD2 Homo sapiens

Full name:

SMAD family member 2

Synonyms:

JV18, JV18-1, MADH2, MADR2, hMAD-2, hSMAD2, mothers against decapentaplegic homolog 2, MAD homolog 2, SMAD, mothers against DPP homolog 2, Sma- and Mad-related protein 2, mother against DPP homolog 2

Genomic Location:

Chr 18: 43613464-43711510

Description:

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the tran...

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The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  CACGTG_MYC_Q2 ,  NFY_C ,  AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D ,  MAX_01 ,  CAGCACT_MIR5123P ,  GGTGTGT_MIR329 ,  MYCMAX_02 ,  GCACCTT_MIR18A_MIR18B ,  NFY_Q6_01 ,  ALPHACP1_01 ,  MYCMAX_01 ,  GGGCGGR_SP1_Q6 ,  NFY_01 ,  HMX1_01 ,  NFY_Q6 ,  CTTTGT_LEF1_Q2 ,  GCTNWTTGK_UNKNOWN ,  CCAATNNSNNNGCG_UNKNOWN ,  AACTTT_UNKNOWN ,  GGGTGGRR_PAX4_03

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-18 ,  Predicted Gene Targets for miR-189 ,  Predicted Gene Targets for miR-329 ,  Predicted Gene Targets for miR-93 ,  Predicted Gene Targets for miR-151

Cytogenetic Map:

18q21.1

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