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QuickView for SMAD4;jsessionid=AACAFDC533D752A308470DC3D7264154 (gene)


Gene Symbol:
SMAD4 Homo sapiens Homo sapiens
Full name:
SMAD family member 4
Synonyms:
DPC4, JIP, MADH4, MYHRS, mothers against decapentaplegic homolog 4, MAD homolog 4, SMAD, mothers against DPP homolog 4, deleted in pancreatic carcinoma locus 4, deletion target in pancreatic carcinoma 4, mothers against decapentaplegic, Drosophila, homolog of, 4
Genomic Location:
Chr 18: 46810611-46860145
Description:
This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to transforming growth factor (TGF)-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad protei...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Macaca mulatta Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 18
18q21.2


Transcripts Names
NM_005359
Protein Names
A8K405
A0A024R274
Q13485



GO Molecular Function

sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | cation binding | proximal promoter sequence-specific DNA binding | nucleic acid binding | protein-containing complex binding | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | chromatin binding | transforming growth factor beta receptor, common-partner cytoplasmic mediator activity | anion binding | collagen binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | sulfate binding | identical protein binding | protein heterodimerization activity | ion binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | I-SMAD binding | protein binding | protein homodimerization activity | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | transcription factor binding | RNA polymerase II transcription factor binding | protein dimerization activity | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | transforming growth factor beta receptor, cytoplasmic mediator activity | transcription coregulator activity | SMAD binding | metal ion binding | heterocyclic compound binding | R-SMAD binding

GO Biological Process

protein modification by small protein removal | RNA metabolic process | transcription by RNA polymerase II | regulation of ERK1 and ERK2 cascade | negative regulation of phosphorylation | limb development | regulation of supramolecular fiber organization | protein homooligomerization | SMAD protein signal transduction | cell morphogenesis | regulation of muscle system process | ventricular cardiac muscle tissue morphogenesis | negative regulation of cardiac myofibril assembly | positive regulation of macromolecule biosynthetic process | negative regulation of MAPK cascade | response to cytokine | positive regulation of cellular component organization | left ventricular cardiac muscle tissue morphogenesis | neuron projection morphogenesis | developmental process involved in reproduction | muscle tissue development | interleukin-6-mediated signaling pathway | intracellular signal transduction | ovarian follicle development | atrioventricular valve formation | proteolysis | regulation of cell development | regulation of localization | morphogenesis of an epithelium | somatic stem cell population maintenance | gonad development | regulation of cardiac muscle cell differentiation | female gonad development | regulation of transforming growth factor beta receptor signaling pathway | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | positive regulation of developmental process | pri-miRNA transcription by RNA polymerase II | negative regulation of RNA biosynthetic process | embryonic appendage morphogenesis | cell differentiation | endothelial cell differentiation | male gamete generation | nervous system development | epithelial to mesenchymal transition | negative regulation of protein phosphorylation | cellular chemical homeostasis | cell part morphogenesis | neurogenesis | epithelial to mesenchymal transition involved in endocardial cushion formation | positive regulation of phosphate metabolic process | regulation of organelle organization | generation of neurons | mesenchyme development | pattern specification process | positive regulation of cellular biosynthetic process | cellular process | negative regulation of muscle organ development | cellular homeostasis | cell projection morphogenesis | epithelial tube morphogenesis | limb morphogenesis | heart morphogenesis | negative regulation of signaling | developmental growth | neuron development | reproductive system development | positive regulation of epithelial to mesenchymal transition | mesoderm development | positive regulation of pathway-restricted SMAD protein phosphorylation | multicellular organismal reproductive process | negative regulation of nucleic acid-templated transcription | renal tubule morphogenesis | stem cell population maintenance | regulation of striated muscle tissue development | regulation of histone modification | branching involved in ureteric bud morphogenesis | response to hypoxia | axon guidance | response to growth factor | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | tissue development | regulation of binding | regulation of histone H3-K9 acetylation | regulation of cell differentiation | gamete generation | muscle structure development | ventricular septum morphogenesis | negative regulation of muscle hypertrophy | regulation of cellular process | negative regulation of cardiocyte differentiation | regulation of metabolic process | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | epithelium development | cellular aromatic compound metabolic process | cellular component organization | protein deubiquitination | response to transforming growth factor beta | urogenital system development | nephron tubule morphogenesis | development of primary sexual characteristics | negative regulation of cardiac muscle tissue development | muscle organ morphogenesis | regulation of histone methylation | response to stimulus | cell morphogenesis involved in neuron differentiation | embryonic limb morphogenesis | positive regulation of protein metabolic process | negative regulation of striated muscle cell differentiation | somite rostral/caudal axis specification | regulation of SMAD protein signal transduction | response to stress | neuron projection guidance | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | roof of mouth development | tube morphogenesis | cardiac muscle tissue development | muscle tissue morphogenesis | development of primary female sexual characteristics | protein homotrimerization | reproduction | atrioventricular valve morphogenesis | cardiac ventricle morphogenesis | cellular nitrogen compound metabolic process | endothelial cell activation | positive regulation of hormone secretion | negative regulation of muscle tissue development | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | negative regulation of metabolic process | positive regulation of BMP signaling pathway | positive regulation of RNA biosynthetic process | cellular component assembly | endocardial cell differentiation | protein modification process | female gonad morphogenesis | cellular biosynthetic process | kidney development | embryo development | macromolecule modification | negative regulation of ERK1 and ERK2 cascade | positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus | metal ion homeostasis | anterior/posterior pattern specification | neuron fate commitment | regulation of nucleic acid-templated transcription | formation of anatomical boundary | locomotion | response to BMP | cellular response to interleukin-6 | endocardial cushion development | system development | brainstem development | response to oxygen levels | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | positive regulation of organelle organization | endothelium development | ureteric bud development | negative regulation of growth | heart valve formation | negative regulation of phosphate metabolic process | regulation of actin cytoskeleton organization | multicellular organism development | regulation of MAPK cascade | regulation of BMP signaling pathway | protein complex oligomerization | regulation of actomyosin structure organization | regulation of phosphorylation | kidney morphogenesis | nephrogenic mesenchyme morphogenesis | regulation of hormone levels | regulation of hormone secretion | positive regulation of chromosome organization | cardiac epithelial to mesenchymal transition | seminiferous tubule development | regulation of gene expression | kidney epithelium development | axon development | positive regulation of secretion | outflow tract morphogenesis | endocardial cushion morphogenesis | embryonic axis specification | negative regulation of cardiac muscle cell differentiation | regulation of epidermis development | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | cellular ion homeostasis | animal organ morphogenesis | positive regulation of luteinizing hormone secretion | negative regulation of cardiac muscle hypertrophy | regulation of nitrogen compound metabolic process | enzyme linked receptor protein signaling pathway | cytokine-mediated signaling pathway | cardiocyte differentiation | regulation of hair follicle development | regulation of transcription by RNA polymerase II | axonogenesis | positive regulation of cell differentiation | stem cell differentiation | cellular response to cytokine stimulus | regulation of cell proliferation involved in heart morphogenesis | positive regulation of histone H3-K9 acetylation | cell proliferation | biosynthetic process | gonad morphogenesis | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | positive regulation of SMAD protein signal transduction | fertilization | mesenchyme morphogenesis | mesonephric epithelium development | cardiac septum morphogenesis | cellular protein-containing complex assembly | metanephric mesenchyme morphogenesis | positive regulation of follicle-stimulating hormone secretion | positive regulation of cell proliferation involved in heart valve morphogenesis | skin development | cell morphogenesis involved in differentiation | mesonephros development | cation homeostasis | gastrulation with mouth forming second | chordate embryonic development | striated muscle tissue development | cellular cation homeostasis | cardiac muscle tissue morphogenesis | cell communication | regulation of cellular metabolic process | positive regulation of histone H3-K4 methylation | transmembrane receptor protein serine/threonine kinase signaling pathway | protein trimerization | metanephros development | anterior/posterior axis specification | renal tubule development | regulation of endocrine process | regulation of protein metabolic process | positive regulation of signal transduction | regulation of histone H3-K4 methylation | negative regulation of striated muscle tissue development | heart development | homeostatic process | positive regulation of cell proliferation | regulation of protein phosphorylation | embryo development ending in birth or egg hatching | iron ion homeostasis | regulation of RNA metabolic process | positive regulation of protein acetylation | renal system development | positive regulation of transport | negative regulation of cell growth | regulation of cellular response to growth factor stimulus | regulation of cell proliferation involved in heart valve morphogenesis | single fertilization | embryonic morphogenesis | nephron development | cellular response to transforming growth factor beta stimulus | secondary palate development | neuron differentiation | multicellular organism reproduction | protein-containing complex assembly | development of primary male sexual characteristics | ureteric bud morphogenesis | heart valve development | ventricular septum development | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | protein metabolic process | regulation of cardiac muscle hypertrophy | DNA-binding transcription factor activity | regionalization | cardiac ventricle development | axis specification | positive regulation of protein modification process | regulation of growth | response to organic substance | gland development | regulation of cardiac muscle tissue development | SMAD protein complex assembly | tissue morphogenesis | branching morphogenesis of an epithelial tube | endocardium development | male sex differentiation | regulation of animal organ morphogenesis | regulation of intracellular signal transduction | positive regulation of peptidyl-lysine acetylation | negative regulation of intracellular signal transduction | ventricular cardiac muscle tissue development | anatomical structure development | cell surface receptor signaling pathway | cell projection organization | metabolic process | cell fate commitment | mesenchymal cell differentiation | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | male gonad development | negative regulation of cytoskeleton organization | chemical homeostasis | regulation of secretion | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | nucleobase-containing compound metabolic process | neuron projection development | atrioventricular canal development | heart valve morphogenesis | organic substance metabolic process | maintenance of cell number | negative regulation of biosynthetic process | negative regulation of gene expression | nephron morphogenesis | animal organ development | positive regulation of histone modification | negative regulation of cellular protein metabolic process | gene expression | ion homeostasis | protein modification by small protein conjugation or removal | regulation of heart morphogenesis | regulation of striated muscle cell differentiation | regulation of phosphate metabolic process | regulation of chromosome organization | regulation of transforming growth factor beta2 production | cellular iron ion homeostasis | atrioventricular valve development | transcription, DNA-templated | nephrogenic mesenchyme development | cell activation | morphogenesis of a branching epithelium | transforming growth factor beta receptor signaling pathway | anatomical structure formation involved in morphogenesis | uterus development | negative regulation of protein metabolic process | positive regulation of transforming growth factor beta receptor signaling pathway | BMP signaling pathway | positive regulation of cell proliferation involved in heart morphogenesis | regulation of cell communication | negative regulation of signal transduction | signaling | somite development | regulation of transcription, DNA-templated | cell development | embryonic digit morphogenesis | positive regulation of phosphorylation | cellular protein metabolic process | regulation of follicle-stimulating hormone secretion | regulation of cytokine production | endocardial cushion formation | endoderm development | morphogenesis of a branching structure | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | reproductive structure development | regulation of developmental process | segmentation | developmental process | regulation of muscle cell differentiation | regulation of cell growth | spermatogenesis | cardiac septum development | cellular protein modification process | regulation of histone acetylation | negative regulation of transcription by RNA polymerase II | tube development | positive regulation of histone acetylation | regulation of transport | positive regulation of transcription, DNA-templated | negative regulation of cell proliferation | regulation of hair cycle | metanephric mesenchyme development | positive regulation of nucleic acid-templated transcription | neural crest cell differentiation | transcription coregulator activity | cellular metal ion homeostasis | epithelial cell differentiation | positive regulation of transcription by RNA polymerase II | regulation of epithelial to mesenchymal transition | negative regulation of supramolecular fiber organization | cardiac chamber development | heterocycle metabolic process | somitogenesis | negative regulation of muscle cell differentiation | in utero embryonic development | positive regulation of metabolic process | regulation of actin filament-based process | cellular response to BMP stimulus | transition metal ion homeostasis | positive regulation of histone methylation | gastrulation | cellular metabolic process | sebaceous gland development | female sex differentiation | cellular response to organic substance | regulation of cell death | sex differentiation | regulation of organelle assembly | response to interleukin-6 | negative regulation of cell death | negative regulation of cell development | circulatory system development | chemotaxis | sexual reproduction | nephron tubule development | negative regulation of cell differentiation | regulation of cellular component organization | muscle organ development | regulation of cytoskeleton organization | positive regulation of signaling | cardiac left ventricle morphogenesis | signal transduction | regulation of signaling | mesonephric tubule development | regulation of pathway-restricted SMAD protein phosphorylation | positive regulation of gene expression | embryonic pattern specification | outflow tract septum morphogenesis | cellular response to growth factor stimulus | regulation of muscle organ development | macromolecule metabolic process | multicellular organismal process | regulation of chromatin organization | regulation of phosphorus metabolic process

GO Cellular Component

nuclear transcription factor complex | activin responsive factor complex | chromosome | intracellular membrane-bounded organelle | microtubule organizing center | RNA polymerase II transcription factor complex | cell | nuclear lumen | transcription factor complex | SMAD protein complex | cytoplasm | intracellular organelle | centrosome | protein-containing complex | nucleoplasm | chromatin | nuclear chromosome | microtubule cytoskeleton | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | nuclear chromatin | cytosol | cytoskeleton | intracellular