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QuickView for SMARCA5 (gene)


Gene Symbol:
SMARCA5 Homo sapiens Homo sapiens
Full name:
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
Synonyms:
ISWI, SNF2H, WCRF135, hISWI, hSNF2H, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5, sucrose nonfermenting protein 2 homolog, sucrose nonfermenting-like 5
Genomic Location:
Chr 4: 144654066-144694017
Description:
The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The protein encoded by this gene is a component of the chromatin remodeling and spacing factor R...
Orthologs:
Mus musculus Rattus norvegicus Saccharomyces cerevisiae Macaca mulatta Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 4
4q31.21


Transcripts Names
NM_003601
XR_001741338
Protein Names
O60264



GO Molecular Function

RNA polymerase II transcription factor activity, sequence-specific DNA binding | nucleosome binding | nucleic acid binding | protein-containing complex binding | ribonucleotide binding | nucleotide binding | hydrolase activity | carbohydrate derivative binding | ATPase activity | pyrophosphatase activity | catalytic activity | chromatin binding | ATP binding | anion binding | adenyl nucleotide binding | nucleoside-triphosphatase activity | DNA binding | purine nucleotide binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | DNA-binding transcription factor activity | hydrolase activity, acting on acid anhydrides | histone binding | purine ribonucleotide binding | adenyl ribonucleotide binding | helicase activity | drug binding | heterocyclic compound binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | small molecule binding

GO Biological Process

RNA metabolic process | DNA-templated transcription, initiation | positive regulation of macromolecule biosynthetic process | response to cytokine | nucleosome organization | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | negative regulation of RNA biosynthetic process | positive regulation of cellular biosynthetic process | cellular process | regulation of gene expression, epigenetic | chromatin organization | CENP-A containing chromatin organization | negative regulation of nucleic acid-templated transcription | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | regulation of cellular process | gene silencing | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular component organization | CENP-A containing nucleosome assembly | response to stimulus | cellular nitrogen compound biosynthetic process | protein-DNA complex assembly | cellular nitrogen compound metabolic process | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | cellular component assembly | cellular biosynthetic process | regulation of nucleic acid-templated transcription | nitrogen compound metabolic process | ATP-dependent chromatin remodeling | regulation of gene expression | centromere complex assembly | negative regulation of gene expression, epigenetic | positive regulation of cellular metabolic process | DNA replication-independent nucleosome assembly | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | positive regulation of gene expression, epigenetic | cellular response to cytokine stimulus | biosynthetic process | aromatic compound biosynthetic process | cellular protein-containing complex assembly | regulation of cellular metabolic process | chromatin remodeling | nucleosome positioning | regulation of RNA metabolic process | protein-containing complex assembly | DNA-binding transcription factor activity | response to organic substance | chromatin assembly or disassembly | metabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | gene expression | chromatin silencing at rDNA | DNA packaging | transcription, DNA-templated | chromatin assembly | cellular response to leukemia inhibitory factor | regulation of transcription, DNA-templated | histone exchange | cellular macromolecule biosynthetic process | organelle organization | DNA replication-independent nucleosome organization | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | DNA conformation change | heterocycle metabolic process | nucleosome assembly | positive regulation of metabolic process | chromosome organization | chromatin silencing | chromatin remodeling at centromere | cellular metabolic process | cellular response to organic substance | positive regulation of gene expression | macromolecule metabolic process

GO Cellular Component

chromosome | intracellular membrane-bounded organelle | catalytic complex | nuclear replication fork | fibrillar center | cell | nuclear lumen | nuclear transcriptional repressor complex | replication fork | nucleolus | intracellular organelle | protein-containing complex | nucleoplasm | chromatin | NURF complex | nuclear chromosome | ISWI-type complex | RSF complex | membrane-bounded organelle | transcriptional repressor complex | nucleus | organelle | SWI/SNF superfamily-type complex | membrane-enclosed lumen | nuclear chromatin | ATPase complex | chromatin silencing complex | intracellular | condensed chromosome