QuickView for SMS (gene)

Gene Symbol:

SMS Homo sapiens

Full name:

spermine synthase

Synonyms:

MRSR, SPMSY, SRS, SpS, spermine synthase, spermidine aminopropyltransferase

Genomic Location:

Chr X: 21868763-21922876

Description:

This gene encodes a protein belonging to the spermidine/spermin synthase family and catalyzes the production of spermine from spermidine. Pseudogenes of this gene are located on chromosomes 1, 5, 6 and X. Mutations in this gene cause an X-linked intellectual disability called Snyder-Robinson Syndrome (SRS). Multiple transcript variants encoding dif...

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This gene encodes a protein belonging to the spermidine/spermin synthase family and catalyzes the production of spermine from spermidine. Pseudogenes of this gene are located on chromosomes 1, 5, 6 and X. Mutations in this gene cause an X-linked intellectual disability called Snyder-Robinson Syndrome (SRS). Multiple transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GGGNRMNNYCAT_UNKNOWN ,  GTGACGY_E4F1_Q6 ,  CAGGTG_E12_Q6 ,  TGCACTG_MIR148A_MIR152_MIR148B ,  AGTCAGC_MIR345 ,  BACH2_01 ,  CREB_02 ,  AATGTGA_MIR23A_MIR23B ,  CREB_Q2 ,  RGAGGAARY_PU1_Q6 ,  ELK1_02 ,  TGGTGCT_MIR29A_MIR29B_MIR29C

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-148 ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-323 ,  Predicted Gene Targets for miR-29

Cytogenetic Map:

Xp22.11

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