QuickView for SMURF1;jsessionid=9E003ACDB8773ABA4447750E575D6318 (gene)

Gene Symbol:

SMURF1 Homo sapiens

Full name:

SMAD specific E3 ubiquitin protein ligase 1

Synonyms:

E3 ubiquitin-protein ligase SMURF1, E3 ubiquitin ligase SMURF1, HECT-type E3 ubiquitin transferase SMURF1, Smad ubiquitination regulatory factor 1, Smad-specific E3 ubiquitin ligase 1, hSMURF1

Genomic Location:

Chr 7: 98463000-98579659

Description:

This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms.

This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CCAGGTT_MIR490 ,  DBP_Q6 ,  CATTTCA_MIR203 ,  CTCAGGG_MIR125B_MIR125A ,  CACCAGC_MIR138 ,  ATATGCA_MIR448 ,  CCATCCA_MIR432 ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-125 ,  Predicted Gene Targets for miR-138 ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-194 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-503 ,  Predicted Gene Targets for miR-203 ,  Predicted Gene Targets for miR-490 ,  Predicted Gene Targets for miR-495

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Cytogenetic Map:

7q22.1

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