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QuickView for SMYD2 (gene)


Gene Symbol:
SMYD2 Homo sapiens Homo sapiens
Full name:
SET and MYND domain containing 2
Synonyms:
HSKM-B, KMT3C, ZMYND14, N-lysine methyltransferase SMYD2, SET and MYND domain-containing protein 2, histone methyltransferase SMYD2, lysine N-methyltransferase 3C, zinc finger, MYND domain containing 14
Genomic Location:
Chr 1: 212521199-212577097
Description:
SET domain-containing proteins, such as SMYD2, catalyze lysine methylation (Brown et al., 2006 [PubMed 16805913]).
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Danio rerio Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 1
1q32.3


Transcripts Names
NM_020197
XM_001127274
XR_426790
Protein Names
B2R9P9
Q9NRG4
Q5VSH9
Q96AI4
Q4V765



GO Molecular Function

RNA polymerase II complex binding | histone-lysine N-methyltransferase activity | lysine N-methyltransferase activity | protein methyltransferase activity | RNA polymerase binding | cation binding | enzyme binding | S-adenosylmethionine-dependent methyltransferase activity | catalytic activity | p53 binding | RNA polymerase core enzyme binding | histone methyltransferase activity | ion binding | protein binding | N-methyltransferase activity | transferase activity | histone methyltransferase activity (H3-K36 specific) | protein-lysine N-methyltransferase activity | methyltransferase activity | metal ion binding | basal RNA polymerase II transcription machinery binding

GO Biological Process

RNA metabolic process | peptidyl-amino acid modification | negative regulation of cellular process | negative regulation of RNA biosynthetic process | histone modification | histone-lysine N-methyltransferase activity | lysine N-methyltransferase activity | protein methyltransferase activity | cellular process | chromatin organization | regulation of DNA damage response, signal transduction by p53 class mediator | negative regulation of nucleic acid-templated transcription | negative regulation of cellular metabolic process | regulation of cellular process | regulation of metabolic process | S-adenosylmethionine-dependent methyltransferase activity | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular component organization | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | cellular nitrogen compound metabolic process | negative regulation of metabolic process | protein modification process | cellular biosynthetic process | macromolecule modification | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | system development | nitrogen compound metabolic process | regulation of signal transduction | multicellular organism development | histone methylation | regulation of gene expression | methylation | regulation of signal transduction by p53 class mediator | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | biosynthetic process | aromatic compound biosynthetic process | peptidyl-lysine monomethylation | histone methyltransferase activity | peptidyl-lysine dimethylation | regulation of cellular metabolic process | heart development | regulation of RNA metabolic process | histone H3-K36 methylation | protein metabolic process | peptidyl-lysine methylation | N-methyltransferase activity | regulation of intracellular signal transduction | anatomical structure development | metabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | peptidyl-lysine modification | regulation of response to DNA damage stimulus | nucleobase-containing compound metabolic process | organic substance metabolic process | histone lysine methylation | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | gene expression | histone methyltransferase activity (H3-K36 specific) | transcription, DNA-templated | regulation of cell communication | covalent chromatin modification | regulation of transcription, DNA-templated | protein-lysine N-methyltransferase activity | cellular protein metabolic process | cellular macromolecule biosynthetic process | protein methylation | methyltransferase activity | developmental process | organelle organization | cellular protein modification process | negative regulation of transcription by RNA polymerase II | negative regulation of cell proliferation | heterocycle metabolic process | chromosome organization | cellular metabolic process | circulatory system development | regulation of signaling | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | nucleoplasm | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cytosol | intracellular