QuickView for SOAT1 (gene)
- Gene Symbol:
- SOAT1
Homo sapiens - Full name:
- sterol O-acyltransferase 1
- Synonyms:
- ACACT, ACAT, ACAT-1, ACAT1, SOAT, STAT, sterol O-acyltransferase 1, acyl-coenzyme A:cholesterol acyltransferase 1, sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1
- Genomic Location:
- Chr 1: 177529640-177591076
- Description:
-
The protein encoded by this gene belongs to the acyltransferase family. It is located in the endoplasmic reticulum, and catalyzes the formation of fatty acid-cholesterol esters. This gene has been implicated in the formation of beta-amyloid and atherosclerotic plaques by controlling the equilibrium between free cholesterol and cytoplasmic cholester...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
CGTSACG_PAX3_B , E2F4DP1_01 , GATAAGR_GATA_C , E2F_Q6 , GTGACGY_E4F1_Q6 , E2F_Q4 , E2F1DP2_01 , AHRARNT_01 , E2F1DP1_01 , E2F1DP1RB_01
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
1q25.2
GO Molecular Function
cofactor binding | transferase activity, transferring acyl groups other than amino-acyl groups | ribonucleotide binding | lipid binding | fatty-acyl-CoA binding | sterol binding | nucleotide binding | coenzyme binding | carbohydrate derivative binding | alcohol binding | catalytic activity | transferase activity, transferring acyl groups | anion binding | adenyl nucleotide binding | amide binding | purine nucleotide binding | cholesterol O-acyltransferase activity | ion binding | organic cyclic compound binding | cholesterol binding | sterol O-acyltransferase activity | protein binding | transferase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | steroid binding | heterocyclic compound binding | small molecule binding | O-acyltransferase activity
GO Biological Process
positive regulation of macromolecule biosynthetic process | macrophage derived foam cell differentiation | very-low-density lipoprotein particle assembly | extracellular structure organization | lipid transport | establishment of localization | lipid storage | cell differentiation | protein-lipid complex assembly | sterol esterification | sterol metabolic process | positive regulation of cellular biosynthetic process | cellular process | positive regulation of glycoprotein biosynthetic process | localization | macromolecule localization | positive regulation of nitrogen compound metabolic process | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | cellular component organization | cellular lipid metabolic process | regulation of glycoprotein biosynthetic process | positive regulation of protein metabolic process | alcohol metabolic process | regulation of plasma lipoprotein particle levels | sterol homeostasis | cholesterol homeostasis | positive regulation of amyloid precursor protein biosynthetic process | organic hydroxy compound transport | cellular component assembly | organic hydroxy compound metabolic process | lipid metabolic process | organic substance transport | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | small molecule metabolic process | sterol transport | plasma lipoprotein particle assembly | cholesterol transport | cholesterol efflux | plasma lipoprotein particle clearance | regulation of cellular metabolic process | regulation of protein metabolic process | cholesterol esterification | lipid modification | homeostatic process | protein-containing complex assembly | metabolic process | lipid localization | cholesterol metabolic process | chemical homeostasis | regulation of amyloid precursor protein biosynthetic process | organic substance metabolic process | cholesterol storage | positive regulation of glycoprotein metabolic process | steroid metabolic process | foam cell differentiation | developmental process | positive regulation of metabolic process | cellular metabolic process | low-density lipoprotein particle clearance | lipid homeostasis | multicellular organismal process
GO Cellular Component
integral component of membrane | intracellular membrane-bounded organelle | cell | intrinsic component of membrane | cytoplasm | intracellular organelle | endoplasmic reticulum | nuclear outer membrane-endoplasmic reticulum membrane network | endomembrane system | endoplasmic reticulum membrane | membrane-bounded organelle | organelle | intracellular | membrane
