QuickView for SOCS3 (gene)

Gene Symbol:

SOCS3 Homo sapiens

Full name:

suppressor of cytokine signaling 3

Synonyms:

ATOD4, CIS3, Cish3, SOCS-3, SSI-3, SSI3, suppressor of cytokine signaling 3, STAT-induced STAT inhibitor 3, cytokine-inducible SH2 protein 3

Genomic Location:

Chr 17: 73864454-73867753

Description:

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by ...

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This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Danio rerio ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TTTGCAC_MIR19A_MIR19B ,  CTTTGCA_MIR527 ,  GGCACAT_MIR455 ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  MYCMAX_B ,  GCTTGAA_MIR498 ,  CATTTCA_MIR203 ,  CAGGTG_E12_Q6 ,  AAGCACA_MIR218

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-218 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-203 ,  Predicted Gene Targets for miR-455

miRNA binding sites
(Source: miRecords):

hsa-miR-203 Targeted Genes

Cytogenetic Map:

17q25.3

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