QuickView for SOCS6;jsessionid=EE830067DAED3C0BC030FF168A0F4CBB (gene)

Gene Symbol:

SOCS6 Homo sapiens

Full name:

suppressor of cytokine signaling 6

Synonyms:

CIS-4, CIS4, HSPC060, SOCS-4, SOCS-6, SOCS4, SSI4, STAI4, STATI4, suppressor of cytokine signaling 6, STAT induced STAT inhibitor-4, cytokine-inducible SH2 protein 4, suppressor of cytokine signaling 4

Genomic Location:

Chr 18: 66107117-66148414

Description:

The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine sign...

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The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CACTGTG_MIR128A_MIR128B ,  AAAGGGA_MIR204_MIR211 ,  TTGCACT_MIR130A_MIR301_MIR130B ,  ACTGTGA_MIR27A_MIR27B ,  CATTTCA_MIR203 ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  AATGTGA_MIR23A_MIR23B ,  TGCACTT_MIR519C_MIR519B_MIR519A ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  CACTTTG_MIR520G_MIR520H ,  AAGCACA_MIR218

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-183 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-204 ,  Predicted Gene Targets for miR-218 ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-323 ,  Predicted Gene Targets for miR-503 ,  Predicted Gene Targets for miR-155 ,  Predicted Gene Targets for miR-203 ,  Predicted Gene Targets for miR-544

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Cytogenetic Map:

18q22.2

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