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QuickView for SORL1;jsessionid=254D02B343E6EF13479E09D99C1759B1 (gene)


Gene Symbol:
SORL1 Homo sapiens Homo sapiens
Full name:
sortilin related receptor 1
Synonyms:
C11orf32, LR11, LRP9, SORLA, SorLA-1, gp250, sortilin-related receptor, LDLR relative with 11 ligand-binding repeats, low-density lipoprotein receptor relative with 11 ligand-binding repeats, mosaic protein LR11, sortilin-related receptor, L(DLR class) A repeats containing, sorting protein-related receptor containing LDLR class A repeats
Genomic Location:
Chr 11: 120828130-121005621
Description:
This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded preproprotein is proteolyticall...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Danio rerio Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 11
11q24.1





GO Molecular Function

GTPase binding | peptide binding | amyloid-beta binding | transmembrane signaling receptor activity | enzyme binding | protein-containing complex binding | lipoprotein particle binding | amide binding | signaling receptor activity | ADP-ribosylation factor binding | lipoprotein particle receptor activity | low-density lipoprotein particle receptor activity | low-density lipoprotein particle binding | protein binding | small GTPase binding | cargo receptor activity

GO Biological Process

negative regulation of amyloid-beta formation | negative regulation of metalloendopeptidase activity | negative regulation of phosphorylation | regulation of intracellular protein transport | negative regulation of MAPK cascade | positive regulation of protein localization to early endosome | regulation of neurogenesis | regulation of cellular localization | regulation of cell development | protein localization to vacuole | regulation of localization | lipid transport | establishment of localization | regulation of endocytic recycling | negative regulation of neuron death | negative regulation of cellular process | negative regulation of kinase activity | regulation of MAP kinase activity | cell differentiation | nervous system development | positive regulation of protein catabolic process | negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process | negative regulation of protein phosphorylation | neurogenesis | regulation of protein oligomerization | negative regulation of neurofibrillary tangle assembly | generation of neurons | intracellular transport | positive regulation of protein localization to endosome | negative regulation of proteolysis | regulation of neuron death | sterol metabolic process | cellular process | regulation of cell motility | localization | regulation of early endosome to recycling endosome transport | negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process | protein transport | negative regulation of signaling | macromolecule localization | regulation of proteolysis | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | positive regulation of early endosome to recycling endosome transport | establishment of localization in cell | negative regulation of cellular metabolic process | regulation of binding | regulation of cell differentiation | regulation of cellular process | regulation of metabolic process | regulation of protein complex assembly | organic cyclic compound metabolic process | response to stimulus | lysosomal transport | regulation of cellular protein localization | protein targeting to lysosome | positive regulation of protein metabolic process | intracellular protein transport | negative regulation of protein kinase activity | positive regulation of cellular protein localization | vacuolar transport | alcohol metabolic process | regulation of smooth muscle cell migration | protein retention in Golgi apparatus | cellular localization | negative regulation of aspartic-type peptidase activity | negative regulation of protein oligomerization | regulation of protein exit from endoplasmic reticulum | regulation of protein transport | negative regulation of metabolic process | regulation of peptide transport | negative regulation of amyloid precursor protein catabolic process | regulation of intracellular transport | protein targeting to vacuole | organic hydroxy compound metabolic process | system development | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of phosphate metabolic process | multicellular organism development | negative regulation of catalytic activity | regulation of peptidase activity | regulation of MAPK cascade | regulation of tau-protein kinase activity | regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | lipid metabolic process | regulation of phosphorylation | protein localization to lysosome | negative regulation of peptidase activity | post-Golgi vesicle-mediated transport | organic substance transport | positive regulation of intracellular protein transport | negative regulation of metallopeptidase activity | regulation of nitrogen compound metabolic process | regulation of cell migration | small molecule metabolic process | peptide transport | negative regulation of protein serine/threonine kinase activity | vesicle-mediated transport | regulation of cellular component movement | protein localization to organelle | negative regulation of binding | regulation of cellular protein metabolic process | lipoprotein particle receptor activity | protein maturation | regulation of amyloid precursor protein catabolic process | maintenance of protein location | cell communication | negative regulation of protein binding | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of ER to Golgi vesicle-mediated transport | regulation of protein metabolic process | positive regulation of establishment of protein localization | regulation of protein phosphorylation | regulation of locomotion | Golgi vesicle transport | negative regulation of MAP kinase activity | positive regulation of transport | low-density lipoprotein particle receptor activity | positive regulation of molecular function | protein localization to Golgi apparatus | protein metabolic process | regulation of establishment of protein localization | positive regulation of endocytic recycling | regulation of kinase activity | import into cell | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | establishment of protein localization to organelle | anatomical structure development | positive regulation of choline O-acetyltransferase activity | negative regulation of tau-protein kinase activity | metabolic process | lipid localization | regulation of protein catabolic process | cholesterol metabolic process | cellular protein localization | amide transport | regulation of vesicle-mediated transport | endocytosis | negative regulation of protein complex assembly | organic substance metabolic process | negative regulation of cellular protein metabolic process | gene expression | maintenance of protein location in cell | regulation of phosphate metabolic process | establishment of protein localization to vacuole | negative regulation of inclusion body assembly | establishment of protein localization | positive regulation of intracellular transport | positive regulation of protein transport | negative regulation of protein metabolic process | steroid metabolic process | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | signaling | regulation of protein binding | regulation of amyloid-beta formation | protein localization | cellular protein metabolic process | regulation of endopeptidase activity | cellular macromolecule localization | regulation of nervous system development | regulation of developmental process | receptor-mediated endocytosis | developmental process | regulation of inclusion body assembly | regulation of transport | positive regulation of ER to Golgi vesicle-mediated transport | negative regulation of hydrolase activity | positive regulation of protein exit from endoplasmic reticulum | positive regulation of metabolic process | protein targeting | cargo receptor activity | cellular metabolic process | regulation of protein localization | regulation of cell death | negative regulation of cell death | negative regulation of cell development | negative regulation of cell differentiation | regulation of cellular component organization | signal transduction | regulation of signaling | negative regulation of endopeptidase activity | macromolecule metabolic process | negative regulation of neurogenesis | maintenance of location in cell | multicellular organismal process | regulation of choline O-acetyltransferase activity | regulation of phosphorus metabolic process

GO Cellular Component

integral component of membrane | Golgi stack | intracellular membrane-bounded organelle | organelle membrane | cytoplasmic vesicle | cell | intrinsic component of membrane | cytoplasm | intracellular organelle | lipoprotein particle | endoplasmic reticulum | endosome membrane | nuclear envelope lumen | Golgi apparatus | protein-containing complex | recycling endosome | Golgi cisterna | endomembrane system | plasma membrane | nuclear envelope | protein-lipid complex | vesicle | extracellular exosome | integral component of plasma membrane | Golgi membrane | endosome | extracellular region | membrane-bounded organelle | extracellular vesicle | low-density lipoprotein particle | nucleus | organelle | extracellular space | cell periphery | membrane-enclosed lumen | early endosome | plasma lipoprotein particle | trans-Golgi network | intracellular vesicle | intracellular | membrane | intrinsic component of plasma membrane