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QuickView for SOX17;jsessionid=1C29E3B8784D6D316B78B7A7FABD91E0 (gene)


Gene Symbol:
SOX17 Homo sapiens Homo sapiens
Full name:
SRY-box 17
Synonyms:
VUR3, transcription factor SOX-17, SRY (sex determining region Y)-box 17, SRY-related HMG-box transcription factor SOX17
Genomic Location:
Chr 8: 55533048-55536009
Description:
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins.
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Canis lupus familiaris Bos taurus Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 8
8q11.23


Transcripts Names
NM_022454
Protein Names
Q9H6I2



GO Molecular Function

sequence-specific DNA binding | beta-catenin binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | nucleic acid binding | DNA binding | protein heterodimerization activity | organic cyclic compound binding | transcription coactivator activity | protein binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | transcription factor binding | protein dimerization activity | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | transcription coregulator activity | heterocyclic compound binding

GO Biological Process

RNA metabolic process | transcription by RNA polymerase II | signal transduction involved in regulation of gene expression | cell morphogenesis | endodermal digestive tract morphogenesis | positive regulation of macromolecule biosynthetic process | blastocyst formation | negative regulation of embryonic development | response to cytokine | cell motility | positive regulation of skeletal muscle tissue development | protein stabilization | morphogenesis of an epithelium | positive regulation of striated muscle tissue development | foregut morphogenesis | cardiogenic plate morphogenesis | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | negative regulation of mesoderm development | neural tube patterning | positive regulation of developmental process | negative regulation of RNA biosynthetic process | cell differentiation | endothelial cell differentiation | male gamete generation | nervous system development | positive regulation of protein catabolic process | endodermal cell fate determination | blood vessel morphogenesis | pattern specification process | positive regulation of cellular biosynthetic process | cellular process | cell fate specification | localization | epithelial tube morphogenesis | heart morphogenesis | negative regulation of signaling | determination of left/right symmetry | canonical Wnt signaling pathway | regulation of embryonic development | negative regulation of mesodermal cell fate specification | multicellular organismal reproductive process | negative regulation of nucleic acid-templated transcription | regulation of striated muscle tissue development | digestive tract morphogenesis | stem cell fate commitment | positive regulation of nitrogen compound metabolic process | regulation of canonical Wnt signaling pathway | negative regulation of cellular metabolic process | tissue development | regulation of cell differentiation | gamete generation | regulation of cellular process | regulation of metabolic process | hepaticobiliary system development | cardiac cell fate determination | organic cyclic compound metabolic process | RNA biosynthetic process | epithelium development | cellular aromatic compound metabolic process | cellular component organization | regulation of cell division | urogenital system development | rostrocaudal neural tube patterning | regulation of mesodermal cell fate specification | response to stimulus | vasculature development | positive regulation of protein metabolic process | determination of heart left/right asymmetry | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | tube morphogenesis | protein destabilization | reproduction | cardiovascular system development | heart formation | cellular nitrogen compound metabolic process | gall bladder development | endodermal cell fate commitment | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | endocardial cell differentiation | mRNA metabolic process | regulation of transcription from RNA polymerase II promoter involved in definitive endodermal cell fate specification | cellular biosynthetic process | embryo development | cell-cell signaling | negative regulation of Wnt signaling pathway involved in heart development | cell surface receptor signaling pathway involved in cell-cell signaling | blood vessel development | anterior/posterior pattern specification | regulation of nucleic acid-templated transcription | common bile duct development | locomotion | regulation of skeletal muscle tissue development | system development | stem cell fate specification | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | endothelium development | Wnt signaling pathway | negative regulation of growth | regulation of protein stability | multicellular organism development | cell migration | positive regulation of muscle organ development | mRNA transcription by RNA polymerase II | determination of bilateral symmetry | regulation of gene expression | regulation of cell fate specification | outflow tract morphogenesis | regulation of stem cell proliferation | embryonic heart tube morphogenesis | positive regulation of cellular metabolic process | animal organ morphogenesis | regulation of nitrogen compound metabolic process | cardiocyte differentiation | regulation of transcription by RNA polymerase II | endoderm formation | positive regulation of cell differentiation | stem cell differentiation | cellular response to cytokine stimulus | biosynthetic process | neural tube development | aromatic compound biosynthetic process | endodermal cell fate specification | angiogenesis | digestive tract development | heart looping | cell morphogenesis involved in differentiation | chordate embryonic development | animal organ formation | cell communication | regulation of cellular metabolic process | regulation of protein metabolic process | vasculogenesis | heart development | mRNA transcription | embryo development ending in birth or egg hatching | transcription coactivator activity | regulation of RNA metabolic process | renal system development | negative regulation of cell growth | negative regulation of cell fate commitment | embryonic morphogenesis | negative regulation of cell fate specification | multicellular organism reproduction | embryonic organ morphogenesis | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | regulation of mesoderm development | DNA-binding transcription factor activity | regionalization | regulation of growth | response to organic substance | tissue morphogenesis | digestive system development | endocardium development | regulation of animal organ morphogenesis | endocardium morphogenesis | regulation of cardiac cell fate specification | embryonic heart tube development | anatomical structure development | cell surface receptor signaling pathway | metabolic process | cell fate commitment | regulation of protein catabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | embryonic organ development | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | gene expression | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | regulation of Wnt signaling pathway | endocardium formation | inner cell mass cellular morphogenesis | positive regulation of muscle tissue development | regulation of transcription involved in cell fate commitment | transcription, DNA-templated | blastocyst development | anatomical structure formation involved in morphogenesis | regulation of cell communication | negative regulation of signal transduction | cellular response to leukemia inhibitory factor | signaling | regulation of transcription, DNA-templated | cell development | cell migration involved in gastrulation | endodermal cell differentiation | endoderm development | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | cell fate commitment involved in formation of primary germ layer | inner cell mass cell differentiation | regulation of developmental process | developmental process | negative regulation of canonical Wnt signaling pathway | regulation of cell growth | spermatogenesis | negative regulation of transcription by RNA polymerase II | tube development | regulation of gastrulation | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | cell fate determination | transcription coregulator activity | epithelial cell differentiation | formation of primary germ layer | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | regulation of cell fate commitment | in utero embryonic development | positive regulation of metabolic process | negative regulation of Wnt signaling pathway | gastrulation | embryonic foregut morphogenesis | cellular metabolic process | regulation of stem cell division | ameboidal-type cell migration | cellular response to organic substance | circulatory system development | sexual reproduction | negative regulation of cell differentiation | regulation of cellular component organization | signal transduction | regulation of signaling | positive regulation of gene expression | regulation of muscle organ development | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

nuclear transcription factor complex | intracellular membrane-bounded organelle | cell | nuclear lumen | transcription factor complex | intracellular organelle | protein-containing complex | nucleoplasm | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular