QuickView for SOX4 (gene)

Gene Symbol:

SOX4 Homo sapiens

Full name:

SRY-box 4

Synonyms:

EVI16, transcription factor SOX-4, SRY (sex determining region Y)-box 4, SRY-related HMG-box gene 4, ecotropic viral integration site 16

Genomic Location:

Chr 6: 21701951-21706829

Description:

This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (synten...

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This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CTTGTAT_MIR381 ,  POU6F1_01 ,  GATTGGY_NFY_Q6_01 ,  GTATTAT_MIR3693P ,  PAX4_04 ,  CACTGCC_MIR34A_MIR34C_MIR449 ,  TTTGCAC_MIR19A_MIR19B ,  TGIF_01 ,  STAT1_02 ,  TTANTCA_UNKNOWN ,  AREB6_02 ,  AAAGGGA_MIR204_MIR211 ,  TTTTGAG_MIR373 ,  POU3F2_01 ,  SYATTGTG_UNKNOWN ,  YTATTTTNR_MEF2_02 ,  TTCCGTT_MIR191 ,  AAANWWTGC_UNKNOWN ,  IPF1_Q4 ,  HP1SITEFACTOR_Q6 ,  AREB6_04 ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  GTAAACC_MIR2995P ,  TAAYNRNNTCC_UNKNOWN ,  TAGCTTT_MIR9 ,  TTGCACT_MIR130A_MIR301_MIR130B ,  STAT1_03 ,  MYCMAX_B ,  EGR2_01 ,  TGACCTY_ERR1_Q2 ,  GTGCAAT_MIR25_MIR32_MIR92_MIR363_MIR367 ,  CTTTGTA_MIR524 ,  GGGAGGRR_MAZ_Q6 ,  SOX9_B1 ,  DBP_Q6 ,  PAX4_02 ,  P53_02 ,  CDX2_Q5 ,  CAGGTG_E12_Q6 ,  CACCAGC_MIR138 ,  CCAWYNNGAAR_UNKNOWN ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  NF1_Q6 ,  GCAAAAA_MIR129 ,  GGGCGGR_SP1_Q6 ,  PITX2_Q2 ,  AAGGGAT_MIR188 ,  ACTGCCT_MIR34B ,  NKX61_01 ,  PAX6_01 ,  TGCCAAR_NF1_Q6 ,  GCCNNNWTAAR_UNKNOWN ,  POU1F1_Q6 ,  NF1_Q6_01 ,  TGTTTGY_HNF3_Q6 ,  GACTGTT_MIR212_MIR132 ,  AHRARNT_01 ,  PTF1BETA_Q6 ,  YCATTAA_UNKNOWN ,  RNGTGGGC_UNKNOWN ,  GFI1_01 ,  MEIS1AHOXA9_01 ,  ELK1_01 ,  CHOP_01 ,  CEBP_C ,  CART1_01 ,  PIT1_Q6 ,  AFP1_Q6 ,  MSX1_01 ,  IRF7_01 ,  TEF_Q6 ,  CTGCAGY_UNKNOWN ,  TGCACTT_MIR519C_MIR519B_MIR519A ,  TGATTTRY_GFI1_01 ,  TCCATTKW_UNKNOWN ,  TGACAGNY_MEIS1_01 ,  AAAGGAT_MIR501 ,  CCATCCA_MIR432 ,  CAGCTG_AP4_Q5 ,  GCTNWTTGK_UNKNOWN ,  AAACCAC_MIR140 ,  AACTTT_UNKNOWN ,  CTGRYYYNATT_UNKNOWN ,  HNF6_Q6 ,  TATTATA_MIR374

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-129 ,  Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-132 ,  Predicted Gene Targets for miR-133 ,  Predicted Gene Targets for miR-138 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-191 ,  Predicted Gene Targets for miR-199 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-208 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-299 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-320 ,  Predicted Gene Targets for miR-329 ,  Predicted Gene Targets for miR-338 ,  Predicted Gene Targets for miR-34 ,  Predicted Gene Targets for miR-34b ,  Predicted Gene Targets for miR-369-3p ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-450 ,  Predicted Gene Targets for miR-539 ,  Predicted Gene Targets for miR-140 ,  Predicted Gene Targets for miR-374 ,  Predicted Gene Targets for miR-411 ,  Predicted Gene Targets for miR-499

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miRNA binding sites
(Source: miRecords):

[miR-335] Targeted Genes

Cytogenetic Map:

6p22.3

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