QuickView for SPARC;jsessionid=FF2AF02F572D622E1C3FF468D3C97815 (gene)

Gene Symbol:

SPARC Homo sapiens

Full name:

secreted protein acidic and cysteine rich

Synonyms:

BM-40, OI17, ON, SPARC, basement-membrane protein 40, secreted protein, acidic, cysteine-rich (osteonectin)

Genomic Location:

Chr 5: 151021201-151046710

Description:

This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based...

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This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. Three transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGANTCA_AP1_C ,  RYTTCCTG_ETS2_B ,  AP3_Q6 ,  HP1SITEFACTOR_Q6 ,  ARP1_01 ,  RNCTGNYNRNCTGNY_UNKNOWN ,  AP1_Q6 ,  GGGAGGRR_MAZ_Q6 ,  CATTTCA_MIR203 ,  RFX1_02 ,  ETS2_B ,  GTTGNYNNRGNAAC_UNKNOWN ,  TGTYNNNNNRGCARM_UNKNOWN ,  BACH1_01 ,  WGGAATGY_TEF1_Q6 ,  GTGGGTGK_UNKNOWN ,  AACTTT_UNKNOWN ,  GGGTGGRR_PAX4_03 ,  CTCCAAG_MIR432

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-339 ,  Predicted Gene Targets for miR-433-3p ,  Predicted Gene Targets for miR-203 ,  Predicted Gene Targets for miR-29 ,  Predicted Gene Targets for miR-452

miRNA binding sites
(Source: miRecords):

hsa-miR-29c Targeted Genes

Cytogenetic Map:

5q33.1

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