QuickView for SPHK2 (gene)

Gene Symbol:

SPHK2 Homo sapiens

Full name:

sphingosine kinase 2

Synonyms:

SK 2, SK-2, SPK 2, SPK-2, sphingosine kinase 2, sphingosine kinase type 2

Genomic Location:

Chr 19: 53814360-53825474

Description:

This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded p...

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This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TTTGCAC_MIR19A_MIR19B ,  CTATGCA_MIR153 ,  TTGCACT_MIR130A_MIR301_MIR130B ,  AAGCAAT_MIR137 ,  CREBP1_Q2 ,  GTGACGY_E4F1_Q6 ,  E2F1_Q6_01 ,  GGGCGGR_SP1_Q6

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-137

Cytogenetic Map:

19q13.33

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