QuickView for SPI1 (gene)

Gene Symbol:

SPI1 Homo sapiens

Full name:

Spi-1 proto-oncogene

Synonyms:

OF, PU.1, SFPI1, SPI-1, SPI-A, transcription factor PU.1, 31 kDa transforming protein, hematopoietic transcription factor PU.1, spleen focus forming virus (SFFV) proviral integration oncogene spi1

Genomic Location:

Chr 11: 47332985-47356703

Description:

This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The prote...

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This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

MYOD_01 ,  CREB_Q4_01 ,  RYTTCCTG_ETS2_B ,  SREBP1_02 ,  STAT6_02 ,  PEA3_Q6 ,  SREBP1_Q6 ,  E2A_Q2 ,  GGGAGGRR_MAZ_Q6 ,  TGAYRTCA_ATF3_Q6 ,  CREBP1_Q2 ,  AGCATTA_MIR155 ,  CAGGTG_E12_Q6 ,  ETS2_B ,  MYOD_Q6 ,  ATF3_Q6 ,  E47_01 ,  CETS1P54_01 ,  MYOGENIN_Q6 ,  RGAGGAARY_PU1_Q6 ,  SREBP_Q3 ,  TGACATY_UNKNOWN ,  CREB_Q2_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-339 ,  Predicted Gene Targets for miR-155

Cytogenetic Map:

11p11.2

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