QuickView for SPRED1;jsessionid=1C29E3B8784D6D316B78B7A7FABD91E0 (gene)

Gene Symbol:

SPRED1 Homo sapiens

Full name:

sprouty related EVH1 domain containing 1

Synonyms:

NFLS, PPP1R147, hSpred1, spred-1, sprouty-related, EVH1 domain-containing protein 1, protein phosphatase 1, regulatory subunit 147, suppressor of Ras/MAPK activation

Genomic Location:

Chr 15: 36331808-36433533

Description:

The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like ...

View Full Description

The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS).

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  GTATTAT_MIR3693P ,  AP1_C ,  TGIF_01 ,  TGANTCA_AP1_C ,  CEBPA_01 ,  AAAGGGA_MIR204_MIR211 ,  ZF5_01 ,  AACTGAC_MIR223 ,  CEBP_Q2_01 ,  YATTNATC_UNKNOWN ,  GTACTGT_MIR101 ,  STAT6_01 ,  TTTNNANAGCYR_UNKNOWN ,  ATGGYGGA_UNKNOWN ,  ATCTTGC_MIR31 ,  CTCNANGTGNY_UNKNOWN ,  TTAYRTAA_E4BP4_01 ,  ATAGGAA_MIR202 ,  CEBP_Q2 ,  NFE2_01 ,  GCTTGAA_MIR498 ,  ACATTCC_MIR1_MIR206 ,  CAGGTG_E12_Q6 ,  AP1_01 ,  TGCGCANK_UNKNOWN ,  AP2_Q6_01 ,  STAT5A_03 ,  AAGGGAT_MIR188 ,  CEBPB_02 ,  CTTTAAR_UNKNOWN ,  MEIS1_01 ,  GACTGTT_MIR212_MIR132 ,  YCATTAA_UNKNOWN ,  GTGCCTT_MIR506 ,  HLF_01 ,  CEBP_Q3 ,  WGGAATGY_TEF1_Q6 ,  TEF_Q6 ,  CTGCAGY_UNKNOWN ,  AAGCACT_MIR520F ,  TCCATTKW_UNKNOWN ,  TGACAGNY_MEIS1_01 ,  EGR1_01 ,  ER_Q6_01 ,  CAGCTG_AP4_Q5 ,  KTGGYRSGAA_UNKNOWN ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  ETS1_B ,  AGGAAGC_MIR5163P ,  CACTTTG_MIR520G_MIR520H ,  ACACTAC_MIR1423P ,  AAGCACA_MIR218 ,  TCF11MAFG_01

View More

View Less

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-126 ,  Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-132 ,  Predicted Gene Targets for miR-142-3p ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-141 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-204 ,  Predicted Gene Targets for miR-218 ,  Predicted Gene Targets for miR-223 ,  Predicted Gene Targets for miR-369-3p ,  Predicted Gene Targets for miR-503 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-155 ,  Predicted Gene Targets for miR-188 ,  Predicted Gene Targets for miR-31 ,  Predicted Gene Targets for miR-410

View More

View Less

Cytogenetic Map:

15q14

search → result