QuickView for SQLE (gene)
- Gene Symbol:
- SQLE
Homo sapiens - Full name:
- squalene epoxidase
- Synonyms:
- squalene monooxygenase, SE
- Genomic Location:
- Chr 8: 126079901-126103707
- Description:
-
Squalene epoxidase catalyzes the first oxygenation step in sterol biosynthesis and is thought to be one of the rate-limiting enzymes in this pathway.
- Orthologs:
- Mus musculus , Rattus norvegicus , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Gallus gallus , Pan troglodytes , Bos taurus , Canis lupus familiaris , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
8q24.13
GO Molecular Function
cofactor binding | nucleotide binding | flavin adenine dinucleotide binding | coenzyme binding | squalene monooxygenase activity | catalytic activity | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | monooxygenase activity | anion binding | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen | ion binding | organic cyclic compound binding | heterocyclic compound binding | oxidoreductase activity | small molecule binding
GO Biological Process
sterol metabolic process | cellular process | regulation of metabolic process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | steroid biosynthetic process | response to stimulus | alcohol metabolic process | squalene monooxygenase activity | regulation of steroid biosynthetic process | regulation of steroid metabolic process | organic hydroxy compound metabolic process | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | monooxygenase activity | lipid metabolic process | regulation of cholesterol biosynthetic process | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen | sterol biosynthetic process | small molecule metabolic process | regulation of cholesterol metabolic process | biosynthetic process | cholesterol biosynthetic process | lipid biosynthetic process | regulation of lipid biosynthetic process | response to organic substance | metabolic process | cholesterol metabolic process | oxidation-reduction process | organic substance metabolic process | steroid metabolic process | regulation of lipid metabolic process | cellular metabolic process | oxidoreductase activity
GO Cellular Component
integral component of membrane | intracellular membrane-bounded organelle | organelle membrane | cell | intrinsic component of membrane | cytoplasm | intracellular organelle | endoplasmic reticulum | nuclear outer membrane-endoplasmic reticulum membrane network | endomembrane system | endoplasmic reticulum membrane | membrane-bounded organelle | organelle | intracellular | membrane
