QuickView for SQSTM1 (gene)

Gene Symbol:

SQSTM1 Homo sapiens

Full name:

sequestosome 1

Synonyms:

A170, DMRV, FTDALS3, NADGP, OSIL, PDB3, ZIP3, p60, p62, p62B, sequestosome-1, EBI3-associated protein of 60 kDa, EBI3-associated protein p60, EBIAP, oxidative stress induced like, phosphotyrosine independent ligand for the Lck SH2 domain p62, phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa, ubiquitin-binding protein p62

Genomic Location:

Chr 5: 179180503-179197684

Description:

This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript va...

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This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Pan troglodytes ,  Gallus gallus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

FOXO1_02 ,  RTAAACA_FREAC2_01 ,  TGANTCA_AP1_C ,  TGANNYRGCA_TCF11MAFG_01 ,  NFE2_01 ,  AP1_Q6_01 ,  FOXO3_01 ,  FREAC3_01 ,  CAGGTG_E12_Q6 ,  AP1_01 ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  AP1_Q2_01 ,  NRF2_Q4 ,  FREAC2_01 ,  BACH1_01 ,  TTGTTT_FOXO4_01 ,  USF_02 ,  AP1_Q4_01 ,  FOXO4_02 ,  GGGTGGRR_PAX4_03 ,  TGASTMAGC_NFE2_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-20

Cytogenetic Map:

5q35.3

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