QuickView for SRD5A1 (gene)
- Gene Symbol:
- SRD5A1
Homo sapiens - Full name:
- steroid 5 alpha-reductase 1
- Synonyms:
- S5AR 1, 3-oxo-5-alpha-steroid 4-dehydrogenase 1, SR type 1, steroid 5-alpha-reductase type I, steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
- Genomic Location:
- Chr 5: 6686500-6722675
- Description:
-
Steroid 5-alpha-reductase (EC 1.3.99.5) catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone (DHT). Also see SRD5A2 (MIM 607306).
- Orthologs:
- Mus musculus , Rattus norvegicus , C. elegans , Macaca mulatta , Schizosaccharomyces pombe , Canis lupus familiaris , Bos taurus , Pan troglodytes , Danio rerio , Gallus gallus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
5p15.31
GO Molecular Function
steroid dehydrogenase activity | NADP binding | cofactor binding | oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor | cholestenone 5-alpha-reductase activity | nucleotide binding | coenzyme binding | catalytic activity | anion binding | electron transfer activity | amide binding | ion binding | organic cyclic compound binding | 3-oxo-5-alpha-steroid 4-dehydrogenase activity | NADPH binding | heterocyclic compound binding | oxidoreductase activity, acting on the CH-CH group of donors | oxidoreductase activity | small molecule binding
GO Biological Process
circadian sleep/wake cycle, sleep | response to extracellular stimulus | brain development | response to nutrient levels | steroid dehydrogenase activity | developmental process involved in reproduction | gonad development | hippocampus development | response to hormone | response to dexamethasone | bone development | cell differentiation | nervous system development | cellular response to extracellular stimulus | response to growth hormone | response to drug | generation of precursor metabolites and energy | cellular response to epinephrine stimulus | response to antibiotic | phenol-containing compound metabolic process | response to organophosphorus | cellular process | reproductive system development | response to estradiol | cellular response to starvation | response to growth factor | diencephalon development | response to peptide hormone | cellular response to lipid | pituitary gland development | hepaticobiliary system development | oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor | organic cyclic compound metabolic process | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | steroid biosynthetic process | cellular lipid metabolic process | cholestenone 5-alpha-reductase activity | urogenital system development | development of primary sexual characteristics | head development | circadian sleep/wake cycle process | response to stimulus | serotonin metabolic process | cellular response to xenobiotic stimulus | response to stress | hypothalamus development | electron transport chain | androgen biosynthetic process | response to peptide | circadian rhythm | response to starvation | reproduction | androgen metabolic process | rhythmic process | cellular nitrogen compound metabolic process | cellular response to organic cyclic compound | circadian sleep/wake cycle | cellular biosynthetic process | regulation of neurotransmitter levels | organic hydroxy compound metabolic process | response to nitrogen compound | cellular response to hormone stimulus | system development | cellular response to nutrient levels | nitrogen compound metabolic process | reproductive process | multicellular organism development | response to activity | cellular response to peptide hormone stimulus | thalamus development | hormone biosynthetic process | response to purine-containing compound | response to follicle-stimulating hormone | cellular response to insulin stimulus | lipid metabolic process | regulation of hormone levels | telencephalon development | electron transfer activity | rhythmic behavior | response to ketone | cellular response to stress | response to lipid | cellular response to peptide | response to epinephrine | cellular response to testosterone stimulus | sleep | liver development | response to corticosteroid | neurotransmitter metabolic process | biosynthetic process | cellular response to glucocorticoid stimulus | lipid biosynthetic process | sex determination | response to toxic substance | response to xenobiotic stimulus | endocrine system development | cellular response to corticosteroid stimulus | cellular response to drug | response to estrogen | cell communication | response to testosterone | response to catecholamine | limbic system development | cerebral cortex development | response to monoamine | development of primary male sexual characteristics | response to organic substance | gland development | male sex differentiation | response to antineoplastic agent | response to insulin | anatomical structure development | metabolic process | oxidation-reduction process | male gonad development | circadian sleep/wake cycle, REM sleep | behavior | organic substance metabolic process | animal organ development | forebrain development | pallium development | diterpenoid metabolic process | 3-oxo-5-alpha-steroid 4-dehydrogenase activity | cellular response to cAMP | cellular response to steroid hormone stimulus | response to gonadotropin | response to cAMP | cellular response to dexamethasone stimulus | response to fungicide | cellular response to estradiol stimulus | steroid metabolic process | response to organic cyclic compound | hormone metabolic process | reproductive structure development | isoprenoid metabolic process | developmental process | circadian behavior | response to organonitrogen compound | heterocycle metabolic process | central nervous system development | spinal cord development | skeletal system development | oxidoreductase activity, acting on the CH-CH group of donors | cellular metabolic process | cellular response to organic substance | sex differentiation | oxidoreductase activity | response to steroid hormone | cellular response to catecholamine stimulus | response to muscle activity | response to glucocorticoid | cellular response to growth factor stimulus | multicellular organismal process
GO Cellular Component
integral component of membrane | intracellular membrane-bounded organelle | neuron projection | somatodendritic compartment | organelle membrane | cell body | cell | neuronal cell body | intrinsic component of membrane | cytoplasm | intracellular organelle | endoplasmic reticulum | nuclear outer membrane-endoplasmic reticulum membrane network | cell projection | endomembrane system | endoplasmic reticulum membrane | perinuclear region of cytoplasm | cell body fiber | membrane-bounded organelle | organelle | intracellular | myelin sheath | membrane
