Correlation Engine 2.0
Clear Search sequence regions
Bookmark Forward

QuickView for SREBP-1C (gene)


Gene Symbol:
Srebf1 Rattus norvegicus Rattus norvegicus
Full name:
sterol regulatory element binding transcription factor 1
Synonyms:
ADD-1, ADD1, SREBP-1, SREBP-1c, Srebp1, sterol regulatory element-binding protein 1, adipocyte determination- and differentiation-dependent factor 1
Genomic Location:
Chr 10: 46460551-46483704
Description:
transcription factor; binds to the sterol regulatory element 1; regulates the transcription of genes important for sterol biosynthesis
Orthologs:
Homo sapiens Mus musculus D. melanogaster C. elegans Macaca mulatta Gallus gallus Canis lupus familiaris Pan troglodytes Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):





GO Molecular Function

sequence-specific DNA binding | kinase binding | enzyme activator activity | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | nuclear receptor activity | transcription factor activity, direct ligand regulated sequence-specific DNA binding | protein kinase binding | proximal promoter sequence-specific DNA binding | enzyme binding | nucleic acid binding | protein-containing complex binding | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | molecular function regulator | chromatin binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | protein dimerization activity | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | sterol response element binding | enzyme regulator activity | heterocyclic compound binding

GO Biological Process

RNA metabolic process | transcription by RNA polymerase II | response to extracellular stimulus | positive regulation of macromolecule biosynthetic process | regulation of intracellular protein transport | response to nutrient levels | positive regulation of cellular component organization | regulation of cellular localization | negative regulation of peptide secretion | enzyme activator activity | regulation of localization | regulation of autophagy | response to hormone | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | negative regulation of RNA biosynthetic process | cell differentiation | respiratory tube development | cellular response to extracellular stimulus | response to drug | negative regulation of protein secretion | regulation of organelle organization | regulation of peptide hormone secretion | response to organophosphorus | sterol metabolic process | positive regulation of cellular biosynthetic process | cellular process | nuclear receptor activity | negative regulation of signaling | response to progesterone | transcription factor activity, direct ligand regulated sequence-specific DNA binding | negative regulation of nucleic acid-templated transcription | regulation of histone modification | negative regulation of secretion | cellular response to starvation | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | negative regulation of hormone secretion | negative regulation of establishment of protein localization | negative regulation of cellular metabolic process | response to peptide hormone | positive regulation of triglyceride biosynthetic process | regulation of cellular process | cellular response to lipid | regulation of metabolic process | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | positive regulation of cholesterol biosynthetic process | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | regulation of peptide secretion | response to stimulus | negative regulation of protein transport | regulation of cellular protein localization | respiratory system development | regulation of insulin secretion | positive regulation of protein metabolic process | response to stress | cellular nitrogen compound biosynthetic process | alcohol metabolic process | positive regulation of lipid biosynthetic process | regulation of heart rate by chemical signal | regulation of blood circulation | response to peptide | circadian rhythm | response to glucose | response to starvation | positive regulation of protein deacetylation | regulation of heart rate | rhythmic process | cellular nitrogen compound metabolic process | negative regulation of transport | regulation of protein transport | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | mRNA metabolic process | regulation of peptide transport | regulation of steroid biosynthetic process | cellular biosynthetic process | regulation of triglyceride metabolic process | regulation of steroid metabolic process | regulation of intracellular transport | molecular function regulator | regulation of nucleic acid-templated transcription | organic hydroxy compound metabolic process | response to nitrogen compound | cellular response to hormone stimulus | system development | cellular response to nutrient levels | nitrogen compound metabolic process | positive regulation of organelle organization | negative regulation of secretion by cell | regulation of protein stability | multicellular organism development | cellular response to peptide hormone stimulus | response to purine-containing compound | response to fatty acid | cellular response to insulin stimulus | regulation of catalytic activity | lipid metabolic process | regulation of hormone levels | regulation of hormone secretion | mRNA transcription by RNA polymerase II | regulation of cholesterol biosynthetic process | positive regulation of chromosome organization | regulation of gene expression | response to ketone | cellular response to stress | response to lipid | cellular response to peptide | insulin receptor signaling pathway | positive regulation of cellular metabolic process | regulation of pri-miRNA transcription by RNA polymerase II | regulation of nitrogen compound metabolic process | enzyme linked receptor protein signaling pathway | small molecule metabolic process | regulation of transcription by RNA polymerase II | fat cell differentiation | regulation of fatty acid metabolic process | regulation of cholesterol metabolic process | positive regulation of steroid metabolic process | biosynthetic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | negative regulation of peptide hormone secretion | positive regulation of pri-miRNA transcription by RNA polymerase II | lipid biosynthetic process | regulation of heart contraction | regulation of mitochondrion organization | positive regulation of histone deacetylation | cell communication | regulation of cellular metabolic process | regulation of protein deacetylation | regulation of protein metabolic process | mRNA transcription | response to monosaccharide | regulation of RNA metabolic process | response to retinoic acid | regulation of lipid biosynthetic process | cellular response to fatty acid | regulation of autophagy of mitochondrion | positive regulation of molecular function | positive regulation of triglyceride metabolic process | response to glucagon | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | regulation of establishment of protein localization | positive regulation of protein modification process | response to organic substance | positive regulation of steroid biosynthetic process | response to insulin | anatomical structure development | cell surface receptor signaling pathway | metabolic process | regulation of protein targeting | regulation of RNA biosynthetic process | cholesterol metabolic process | negative regulation of transcription, DNA-templated | regulation of secretion | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | positive regulation of histone modification | gene expression | regulation of protein secretion | regulation of chromosome organization | positive regulation of cholesterol metabolic process | transcription, DNA-templated | response to cAMP | lung development | intracellular receptor signaling pathway | steroid metabolic process | regulation of cell communication | negative regulation of insulin secretion | signaling | regulation of transcription, DNA-templated | response to organic cyclic compound | enzyme regulator activity | cellular macromolecule biosynthetic process | regulation of cellular ketone metabolic process | developmental process | negative regulation of transcription by RNA polymerase II | tube development | regulation of transport | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | response to organonitrogen compound | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | regulation of histone deacetylation | transmembrane receptor protein tyrosine kinase signaling pathway | regulation of lipid metabolic process | positive regulation of metabolic process | positive regulation of lipid metabolic process | cellular metabolic process | cellular response to organic substance | regulation of protein localization | response to carbohydrate | response to steroid hormone | response to food | aging | regulation of triglyceride biosynthetic process | regulation of cellular component organization | signal transduction | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process | regulation of protein targeting to mitochondrion | regulation of chromatin organization

GO Cellular Component

integral component of membrane | intracellular membrane-bounded organelle | ER to Golgi transport vesicle membrane | organelle membrane | cytoplasmic vesicle | Golgi-associated vesicle membrane | cell | COPII-coated ER to Golgi transport vesicle | intrinsic component of membrane | transport vesicle membrane | cytoplasm | intracellular organelle | endoplasmic reticulum | Golgi apparatus | nuclear outer membrane-endoplasmic reticulum membrane network | protein-containing complex | endomembrane system | endoplasmic reticulum membrane | Golgi-associated vesicle | vesicle | transport vesicle | Golgi membrane | coated vesicle membrane | membrane-bounded organelle | nucleus | organelle | vesicle membrane | intracellular vesicle | intracellular | membrane | cytoplasmic vesicle membrane | coated vesicle