QuickView for SSB (gene)

Gene Symbol:

SSB Homo sapiens

Full name:

Sjogren syndrome antigen B

Synonyms:

LARP3, La, La/SSB, lupus La protein, La ribonucleoprotein domain family, member 3, SS-B, SS-B/La protein, autoantigen La, la autoantigen, lupus La antigen, sjoegren syndrome type B antigen

Genomic Location:

Chr 2: 170363635-170376821

Description:

The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodi...

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The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

WHN_B ,  CTTTGTA_MIR524 ,  GGGCGGR_SP1_Q6 ,  RNGTGGGC_UNKNOWN

Cytogenetic Map:

2q31.1

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