QuickView for STAT3 (gene)

Gene Symbol:

STAT3 Homo sapiens

Full name:

signal transducer and activator of transcription 3

Synonyms:

ADMIO, ADMIO1, APRF, HIES, signal transducer and activator of transcription 3, DNA-binding protein APRF, acute-phase response factor

Genomic Location:

Chr 17: 37718869-37794039

Description:

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosph...

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The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  GATTGGY_NFY_Q6_01 ,  ATAAGCT_MIR21 ,  CREBP1CJUN_01 ,  ATF6_01 ,  HEN1_01 ,  CACGTG_MYC_Q2 ,  CATTGTYY_SOX9_B1 ,  YATTNATC_UNKNOWN ,  XBP1_01 ,  AP2GAMMA_01 ,  STAT6_01 ,  RYCACNNRNNRNCAG_UNKNOWN ,  AP2ALPHA_01 ,  CREB_Q3 ,  ATAGGAA_MIR202 ,  GGGAGGRR_MAZ_Q6 ,  TGAYRTCA_ATF3_Q6 ,  CREBP1_Q2 ,  TFIII_Q6 ,  MYCMAX_02 ,  CEBP_Q2 ,  PAX4_02 ,  GTGACGY_E4F1_Q6 ,  CTCAGGG_MIR125B_MIR125A ,  CTACCTC_LET7A_LET7B_LET7C_LET7D_LET7E_LET7F_MIR98_LET7G_LET7I ,  AP4_01 ,  NKX62_Q2 ,  SP3_Q3 ,  TGCCTTA_MIR124A ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  NF1_Q6 ,  STAT5A_03 ,  CEBPB_02 ,  S8_01 ,  GAANYNYGACNY_UNKNOWN ,  NKX25_02 ,  TCCAGAT_MIR5165P ,  TGCCAAR_NF1_Q6 ,  NF1_Q6_01 ,  CAGCAGG_MIR370 ,  GTGCCTT_MIR506 ,  NMYC_01 ,  TAATTA_CHX10_01 ,  TTGTTT_FOXO4_01 ,  WTTGKCTG_UNKNOWN ,  HEN1_02 ,  CREB_Q2 ,  TGACGTCA_ATF3_Q6 ,  AGGGCAG_MIR18A ,  TGCACTT_MIR519C_MIR519B_MIR519A ,  CTTTGT_LEF1_Q2 ,  CAGCTG_AP4_Q5 ,  CDC5_01 ,  FOXM1_01 ,  AACTTT_UNKNOWN ,  TGACATY_UNKNOWN ,  CREB_01 ,  HNF6_Q6 ,  HTF_01 ,  GGGTGGRR_PAX4_03 ,  TCF11_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-125 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-21 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-410

Cytogenetic Map:

17q21.2

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