QuickView for STAT5B (gene)

Gene Symbol:

STAT5B Homo sapiens

Full name:

signal transducer and activator of transcription 5B

Synonyms:

STAT5, signal transducer and activator of transcription 5B, transcription factor STAT5B

Genomic Location:

Chr 17: 37604721-37681950

Description:

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates t...

View Full Description

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  C. elegans ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

ATGCAGT_MIR217 ,  TTTGCAC_MIR19A_MIR19B ,  AP1_C ,  TGANTCA_AP1_C ,  HNF1_01 ,  ETS_Q4 ,  RYTTCCTG_ETS2_B ,  TGGNNNNNNKCCAR_UNKNOWN ,  EFC_Q6 ,  SRF_Q6 ,  ZF5_01 ,  YATTNATC_UNKNOWN ,  CAGTGTT_MIR141_MIR200A ,  AP1_Q6 ,  GTGCAAA_MIR507 ,  NKX22_01 ,  PBX1_01 ,  CDPCR3HD_01 ,  AP1_Q6_01 ,  TAATGTG_MIR323 ,  GGATTA_PITX2_Q2 ,  AP1FJ_Q2 ,  BACH2_01 ,  GCAAAAA_MIR129 ,  CDPCR1_01 ,  GGGCGGR_SP1_Q6 ,  SRF_Q4 ,  NERF_Q2 ,  GTTGNYNNRGNAAC_UNKNOWN ,  NF1_Q6_01 ,  TGTTTGY_HNF3_Q6 ,  AP1_Q4 ,  YCATTAA_UNKNOWN ,  AATGTGA_MIR23A_MIR23B ,  HAND1E47_01 ,  TAATTA_CHX10_01 ,  TTGTTT_FOXO4_01 ,  WWTAAGGC_UNKNOWN ,  CTGCAGY_UNKNOWN ,  SRF_Q5_01 ,  AP1_Q2 ,  CTTTGT_LEF1_Q2 ,  CAGCTG_AP4_Q5 ,  CRX_Q4 ,  SRF_C

View More

View Less

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-129 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-194 ,  Predicted Gene Targets for miR-141 ,  Predicted Gene Targets for miR-217 ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-323 ,  Predicted Gene Targets for miR-450 ,  Predicted Gene Targets for miR-363

Cytogenetic Map:

17q21.2

search → result