QuickView for STAT5a (gene)

Gene Symbol:

STAT5A Homo sapiens

Full name:

signal transducer and activator of transcription 5A

Synonyms:

MGF, STAT5, signal transducer and activator of transcription 5A

Genomic Location:

Chr 17: 37693091-37717484

Description:

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activat...

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The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Bos taurus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

STAT4_01 ,  TGGNNNNNNKCCAR_UNKNOWN ,  STAT6_02 ,  GCANCTGNY_MYOD_Q6 ,  CAGTGTT_MIR141_MIR200A ,  TGACCTY_ERR1_Q2 ,  NERF_Q2 ,  PTF1BETA_Q6 ,  MYOGENIN_Q6 ,  RGAGGAARY_PU1_Q6 ,  CAGCTG_AP4_Q5 ,  PPAR_DR1_Q2

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-141

Cytogenetic Map:

17q21.2

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