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QuickView for STAT6 (gene)


Gene Symbol:
STAT6 Homo sapiens Homo sapiens
Full name:
signal transducer and activator of transcription 6
Synonyms:
D12S1644, IL-4-STAT, STAT6B, STAT6C, signal transducer and activator of transcription 6, STAT, interleukin4-induced, signal transducer and activator of transcription 6, interleukin-4 induced, transcription factor IL-4 STAT
Genomic Location:
Chr 12: 55775458-55791428
Description:
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a ce...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 12
12q13.3





GO Molecular Function

sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | proximal promoter sequence-specific DNA binding | enzyme binding | nucleic acid binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | identical protein binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | protein phosphatase binding | RNA polymerase II regulatory region sequence-specific DNA binding | phosphatase binding | heterocyclic compound binding

GO Biological Process

positive regulation of immune response | RNA metabolic process | transcription by RNA polymerase II | adaptive immune response | positive regulation of macromolecule biosynthetic process | negative regulation of immune system process | CD4-positive, alpha-beta T cell differentiation | response to cytokine | regulation of B cell activation | CD4-positive, alpha-beta T cell activation | T cell lineage commitment | regulation of immune system process | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | positive regulation of developmental process | negative regulation of RNA biosynthetic process | positive regulation of lymphocyte activation | T-helper cell lineage commitment | cell differentiation | response to drug | positive regulation of DNA recombination | response to antibiotic | positive regulation of cellular biosynthetic process | cellular process | lymphocyte differentiation | positive regulation of immune effector process | positive regulation of adaptive immune response | T-helper 1 type immune response | immune system development | negative regulation of nucleic acid-templated transcription | positive regulation of nitrogen compound metabolic process | CD4-positive or CD8-positive, alpha-beta T cell lineage commitment | response to inorganic substance | negative regulation of cellular metabolic process | tissue development | response to hydrogen peroxide | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of metabolic process | T cell differentiation involved in immune response | organic cyclic compound metabolic process | regulation of type 2 immune response | RNA biosynthetic process | epithelium development | cellular aromatic compound metabolic process | T cell activation | mammary gland morphogenesis | regulation of type I interferon production | response to stimulus | regulation of DNA recombination | positive regulation of cold-induced thermogenesis | alpha-beta T cell activation involved in immune response | positive regulation of immune system process | positive regulation of immunoglobulin production | gland morphogenesis | response to stress | leukocyte activation involved in immune response | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | positive regulation of cell activation | cellular nitrogen compound metabolic process | cellular response to toxic substance | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | hemopoiesis | cellular biosynthetic process | regulation of nucleic acid-templated transcription | T-helper cell differentiation | leukocyte differentiation | response to nitrogen compound | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | system development | nitrogen compound metabolic process | cellular response to antibiotic | multicellular organism development | mammary gland development | cellular response to oxidative stress | positive regulation of isotype switching to IgE isotypes | T-helper 1 cell differentiation | regulation of gene expression | cellular response to stress | alpha-beta T cell lineage commitment | positive regulation of cellular metabolic process | regulation of lymphocyte activation | animal organ morphogenesis | regulation of nitrogen compound metabolic process | cytokine-mediated signaling pathway | regulation of transcription by RNA polymerase II | alpha-beta T cell differentiation | response to oxidative stress | cellular response to cytokine stimulus | cell proliferation | biosynthetic process | negative regulation of type 2 immune response | positive regulation of immunoglobulin mediated immune response | aromatic compound biosynthetic process | negative regulation of immune response | T cell activation involved in immune response | mammary gland epithelial cell proliferation | response to toxic substance | positive regulation of isotype switching | cellular response to drug | cell communication | regulation of cellular metabolic process | cell activation involved in immune response | regulation of RNA metabolic process | positive regulation of B cell activation | lymphocyte activation | T cell differentiation | cellular response to interleukin-4 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | T cell selection | response to organic substance | gland development | epithelial cell proliferation | cellular response to reactive nitrogen species | anatomical structure development | cell surface receptor signaling pathway | interleukin-4-mediated signaling pathway | metabolic process | cell fate commitment | regulation of isotype switching | regulation of adaptive immune response | regulation of RNA biosynthetic process | positive regulation of leukocyte activation | negative regulation of transcription, DNA-templated | positive T cell selection | cellular response to hydrogen peroxide | immune response | nucleobase-containing compound metabolic process | cellular response to reactive oxygen species | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | response to reactive oxygen species | gene expression | regulation of cell activation | alpha-beta T cell activation | mammary gland epithelium development | T-helper 1 cell lineage commitment | transcription, DNA-templated | positive regulation of cytokine production | cell activation | signaling | regulation of immunoglobulin production | regulation of transcription, DNA-templated | regulation of cytokine production | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | regulation of developmental process | positive regulation of DNA metabolic process | developmental process | negative regulation of transcription by RNA polymerase II | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of metabolic process | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | cellular response to organic substance | positive regulation of type I interferon production | signal transduction | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process | response to interleukin-4

GO Cellular Component

chromosome | intracellular membrane-bounded organelle | organelle membrane | nuclear membrane | cell | nuclear lumen | cytoplasm | intracellular organelle | membrane microdomain | endomembrane system | nucleoplasm | nuclear envelope | chromatin | nuclear chromosome | membrane raft | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | nuclear chromatin | cytosol | intracellular | membrane