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QuickView for STXBP2 (gene)


Gene Symbol:
STXBP2 Homo sapiens Homo sapiens
Full name:
syntaxin binding protein 2
Synonyms:
FHL5, Hunc18b, MUNC18-2, UNC18-2, UNC18B, pp10122, syntaxin-binding protein 2, protein unc-18 homolog B, unc-18B
Genomic Location:
Chr 19: 7608011-7618707
Description:
This gene encodes a member of the STXBP/unc-18/SEC1 family. The encoded protein is involved in intracellular trafficking, control of SNARE (soluble NSF attachment protein receptor) complex assembly, and the release of cytotoxic granules by natural killer cells. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis. ...
Orthologs:
Mus musculus Rattus norvegicus Saccharomyces cerevisiae Macaca mulatta Schizosaccharomyces pombe Canis lupus familiaris Danio rerio Bos taurus Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 19
19p13.2





GO Molecular Function

syntaxin binding | protein binding | syntaxin-3 binding | SNARE binding | syntaxin-1 binding

GO Biological Process

exocytosis | response to cytokine | neutrophil activation | regulation of cellular localization | regulation of localization | establishment of localization | regulation of immune system process | platelet degranulation | defense response | cellular process | secretion | leukocyte degranulation | localization | protein transport | positive regulation of immune effector process | macromolecule localization | membrane docking | regulation of immune response | regulation of cellular process | leukocyte activation | organelle localization | regulation of mast cell degranulation | cellular response to interferon-gamma | response to stimulus | neutrophil degranulation | positive regulation of immune system process | response to stress | leukocyte activation involved in immune response | cellular localization | secretion by cell | regulation of intracellular transport | leukocyte mediated immunity | cell killing | organic substance transport | regulation of mast cell activation | peptide transport | vesicle-mediated transport | cellular response to cytokine stimulus | regulated exocytosis | cell activation involved in immune response | myeloid cell activation involved in immune response | neutrophil activation involved in immune response | response to organic substance | regulation of exocytosis | amide transport | regulation of vesicle-mediated transport | regulation of secretion | immune response | leukocyte mediated cytotoxicity | regulation of cell activation | vesicle docking | establishment of protein localization | response to interferon-gamma | regulation of regulated secretory pathway | cell activation | protein localization | vesicle docking involved in exocytosis | regulation of transport | innate immune response | neutrophil mediated immunity | immune system process | cellular response to organic substance

GO Cellular Component

secretory granule | zymogen granule | intracellular membrane-bounded organelle | apical plasma membrane | organelle membrane | tertiary granule | cytoplasmic vesicle | cell | cytoplasm | intracellular organelle | secretory granule membrane | apical part of cell | protein-containing complex | secretory vesicle | endomembrane system | plasma membrane | cytolytic granule | vacuole | vesicle | extracellular exosome | specific granule | lytic vacuole | SNARE complex | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | vesicle membrane | zymogen granule membrane | lysosome | extracellular space | cell periphery | azurophil granule | cytosol | intracellular vesicle | endocytic vesicle | intracellular | membrane | cytoplasmic vesicle membrane | phagocytic vesicle