QuickView for SUCLA2 (gene)

Gene Symbol:

SUCLA2 Homo sapiens

Full name:

succinate-CoA ligase ADP-forming beta subunit

Synonyms:

A-BETA, A-SCS, MTDPS5, SCS-betaA, succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial, succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial, ATP-specific succinyl-CoA synthetase subunit beta, ATP-specific succinyl-CoA synthetase, beta subunit, mitochondrial succinyl-CoA ligase [ADP-forming] subunit beta, renal carcinoma antigen NY-REN-39, succinate--CoA ligase (ADP-forming), succinate-CoA ligase beta subunit, succinyl-CoA synthetase beta-A chain

Genomic Location:

Chr 13: 47414792-47473463

Description:

Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. The protein encoded by this gene is an ATP-specific SCS beta subunit that dimerizes with the SCS alpha subunit to form SCS-A, an essential component of the tricarboxylic acid ...

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Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. The protein encoded by this gene is an ATP-specific SCS beta subunit that dimerizes with the SCS alpha subunit to form SCS-A, an essential component of the tricarboxylic acid cycle. SCS-A hydrolyzes ATP to convert succinate to succinyl-CoA. Defects in this gene are a cause of myopathic mitochondrial DNA depletion syndrome. A pseudogene of this gene has been found on chromosome 6.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

ATTCTTT_MIR186 ,  ATACTGT_MIR144 ,  RORA1_01 ,  ERR1_Q2 ,  SF1_Q6

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-320

Cytogenetic Map:

13q14.2

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