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QuickView for SUFU (gene)


Gene Symbol:
SUFU Homo sapiens Homo sapiens
Full name:
SUFU negative regulator of hedgehog signaling
Synonyms:
JBTS32, PRO1280, SUFUH, SUFUXL, suppressor of fused homolog
Genomic Location:
Chr 10: 104253754-104383199
Description:
The Hedgehog signaling pathway plays an important role in early human development. The pathway is a signaling cascade that plays a role in pattern formation and cellular proliferation during development. This gene encodes a negative regulator of the hedgehog signaling pathway. Defects in this gene are a cause of medulloblastoma. Alternative splicin...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster Macaca mulatta Danio rerio Gallus gallus Pan troglodytes Bos taurus Canis lupus familiaris
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
miRNA binding sites
(Source: miRecords):
Cytogenetic Map:
chr 10
10q24.32





GO Molecular Function

beta-catenin binding | kinase binding | protein kinase binding | enzyme binding | transcription corepressor activity | protein binding | transcription factor binding | transcription coregulator activity

GO Biological Process

negative regulation of intracellular transport | regulation of intracellular protein transport | negative regulation of embryonic development | regulation of cellular localization | proteolysis | regulation of localization | morphogenesis of an epithelium | spinal cord motor neuron differentiation | negative regulation of cellular process | negative regulation of RNA biosynthetic process | regulation of protein import | cell differentiation | ventral spinal cord interneuron fate commitment | nervous system development | neurogenesis | generation of neurons | negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning | negative regulation of proteolysis | pattern specification process | cellular process | cell fate specification | localization | epithelial tube morphogenesis | negative regulation of ubiquitin-dependent protein catabolic process | heart morphogenesis | negative regulation of protein import into nucleus | negative regulation of signaling | central nervous system neuron differentiation | determination of left/right symmetry | regulation of embryonic development | negative regulation of nucleic acid-templated transcription | macromolecule localization | regulation of proteolysis | regulation of smoothened signaling pathway | negative regulation of establishment of protein localization | negative regulation of cellular metabolic process | tissue development | regulation of cell differentiation | regulation of cellular process | regulation of osteoblast differentiation | regulation of metabolic process | epithelium development | negative regulation of protein localization to nucleus | negative regulation of cellular protein catabolic process | spinal cord motor neuron cell fate specification | response to stimulus | negative regulation of protein transport | vasculature development | regulation of cellular protein localization | embryonic epithelial tube formation | regulation of cellular protein catabolic process | determination of heart left/right asymmetry | negative regulation of intracellular protein transport | spinal cord dorsal/ventral patterning | tube morphogenesis | epithelial tube formation | cardiovascular system development | negative regulation of transport | ventral spinal cord interneuron specification | regulation of protein transport | negative regulation of metabolic process | regulation of peptide transport | dorsal/ventral pattern formation | embryo development | regulation of intracellular transport | blood vessel development | neuron fate commitment | regulation of nucleic acid-templated transcription | negative regulation of osteoblast differentiation | system development | ventral spinal cord development | nitrogen compound metabolic process | regulation of signal transduction | multicellular organism development | negative regulation of cellular protein localization | smoothened signaling pathway involved in spinal cord motor neuron cell fate specification | regulation of ossification | artery development | determination of bilateral symmetry | regulation of gene expression | neural tube closure | embryonic heart tube morphogenesis | coronary vasculature development | animal organ morphogenesis | regulation of protein localization to nucleus | regulation of nitrogen compound metabolic process | regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning | cytoplasmic sequestering of protein | negative regulation of DNA-binding transcription factor activity | cell fate specification involved in pattern specification | neural tube formation | transcription corepressor activity | regulation of transcription by RNA polymerase II | neural tube development | regulation of cellular protein metabolic process | cytoplasmic sequestering of transcription factor | heart looping | skin development | maintenance of protein location | chordate embryonic development | cell communication | ventral spinal cord interneuron differentiation | regulation of cellular metabolic process | regulation of protein metabolic process | heart development | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | cell fate commitment involved in pattern specification | embryonic morphogenesis | regulation of nucleocytoplasmic transport | neuron differentiation | embryonic organ morphogenesis | ventricular septum development | protein metabolic process | regulation of establishment of protein localization | regionalization | cardiac ventricle development | tissue morphogenesis | regulation of protein import into nucleus | negative regulation of ossification | regulation of DNA-binding transcription factor activity | embryonic heart tube development | anatomical structure development | cell surface receptor signaling pathway | aorta development | metabolic process | cell fate commitment | smoothened signaling pathway involved in ventral spinal cord interneuron specification | regulation of protein catabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | embryonic organ development | spinal cord patterning | morphogenesis of embryonic epithelium | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | negative regulation of cellular protein metabolic process | smoothened signaling pathway | anatomical structure formation involved in morphogenesis | negative regulation of protein catabolic process | negative regulation of protein metabolic process | cell differentiation in spinal cord | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | smoothened signaling pathway involved in ventral spinal cord patterning | protein localization | anatomical structure morphogenesis | regulation of nervous system development | regulation of developmental process | developmental process | negative regulation of smoothened signaling pathway | cardiac septum development | negative regulation of transcription by RNA polymerase II | tube development | regulation of transport | transcription coregulator activity | tube closure | cardiac chamber development | tube formation | central nervous system development | spinal cord development | skeletal system development | regulation of protein localization | neuron fate specification | circulatory system development | regulation of ubiquitin-dependent protein catabolic process | negative regulation of proteolysis involved in cellular protein catabolic process | negative regulation of cell differentiation | signal transduction | regulation of signaling | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | cell projection | cilium | membrane-bounded organelle | nucleus | organelle | ciliary base | cytosol | ciliary tip | intracellular