QuickView for SUMO1 (gene)

Gene Symbol:

SUMO1 Homo sapiens

Full name:

small ubiquitin-like modifier 1

Synonyms:

DAP1, GMP1, OFC10, PIC1, SENP2, SMT3, SMT3C, SMT3H3, UBL1, small ubiquitin-related modifier 1, GAP modifying protein 1, SMT3 homolog 3, SMT3 suppressor of mif two 3 homolog 1, sentrin, ubiquitin-homology domain protein PIC1, ubiquitin-like protein SMT3C, ubiquitin-like protein UBL1

Genomic Location:

Chr 2: 202779148-202811567

Description:

This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of ...

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This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  C. elegans ,  Saccharomyces cerevisiae ,  Gallus gallus ,  Danio rerio ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TCTGGAC_MIR198 ,  GATTGGY_NFY_Q6_01 ,  RTAAACA_FREAC2_01 ,  E2F4DP1_01 ,  E4BP4_01 ,  HFH1_01 ,  TTAYRTAA_E4BP4_01 ,  WHN_B ,  GGGAGGRR_MAZ_Q6 ,  TAATGTG_MIR323 ,  E2F_Q6 ,  FOXO3_01 ,  GTGACGY_E4F1_Q6 ,  E2F1_Q6_01 ,  E2F_Q4 ,  ATTCTTT_MIR186 ,  CREBP1_01 ,  E2F1DP2_01 ,  GCGNNANTTCC_UNKNOWN ,  GAANYNYGACNY_UNKNOWN ,  MGGAAGTG_GABP_B ,  PAX6_01 ,  HFH8_01 ,  E2F1DP1_01 ,  HLF_01 ,  TTGTTT_FOXO4_01 ,  E2F1DP1RB_01 ,  SCGGAAGY_ELK1_02 ,  E2F_02 ,  E2F1_Q3 ,  ACAWNRNSRCGG_UNKNOWN ,  E2F4DP2_01 ,  FOXO4_02 ,  E2F1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-133 ,  Predicted Gene Targets for miR-150 ,  Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-323

Cytogenetic Map:

2q33.1

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