QuickView for SUZ12 (gene)
- Gene Symbol:
- SUZ12
Homo sapiens - Full name:
- SUZ12 polycomb repressive complex 2 subunit
- Synonyms:
- CHET9, JJAZ1, polycomb protein SUZ12, chET 9 protein, chromatin precipitated E2F target 9 protein, joined to JAZF1 protein, suppressor of zeste 12 protein homolog
- Genomic Location:
- Chr 17: 27288185-27352162
- Description:
-
This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region.
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , Macaca mulatta , Gallus gallus , Canis lupus familiaris , Bos taurus , Danio rerio , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
17q11.2
GO Molecular Function
sequence-specific DNA binding | transcription regulatory region DNA binding | histone-lysine N-methyltransferase activity | lysine N-methyltransferase activity | protein methyltransferase activity | cation binding | proximal promoter sequence-specific DNA binding | nucleic acid binding | S-adenosylmethionine-dependent methyltransferase activity | histone methyltransferase activity (H3-K27 specific) | methylated histone binding | catalytic activity | chromatin binding | modification-dependent protein binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | promoter-specific chromatin binding | histone methyltransferase activity | ion binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | chromatin DNA binding | N-methyltransferase activity | RNA polymerase II regulatory region sequence-specific DNA binding | transferase activity | histone binding | protein-lysine N-methyltransferase activity | methyltransferase activity | metal ion binding | heterocyclic compound binding | RNA binding
GO Biological Process
RNA metabolic process | regulation of cell cycle process | peptidyl-amino acid modification | negative regulation of cellular process | negative regulation of RNA biosynthetic process | histone modification | histone-lysine N-methyltransferase activity | lysine N-methyltransferase activity | protein methyltransferase activity | cellular process | regulation of gene expression, epigenetic | chromatin organization | negative regulation of nucleic acid-templated transcription | regulation of cell cycle | negative regulation of cellular metabolic process | regulation of cell differentiation | regulation of cellular process | regulation of metabolic process | S-adenosylmethionine-dependent methyltransferase activity | histone methyltransferase activity (H3-K27 specific) | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular component organization | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | cellular nitrogen compound metabolic process | negative regulation of metabolic process | protein modification process | cellular biosynthetic process | macromolecule modification | histone H3-K27 methylation | regulation of nucleic acid-templated transcription | nitrogen compound metabolic process | histone methylation | regulation of gene expression | methylation | negative regulation of gene expression, epigenetic | regulation of nitrogen compound metabolic process | protein modification by small protein conjugation | regulation of transcription by RNA polymerase II | negative regulation of G0 to G1 transition | biosynthetic process | aromatic compound biosynthetic process | histone methyltransferase activity | regulation of cellular metabolic process | positive regulation of cell proliferation | regulation of RNA metabolic process | protein metabolic process | peptidyl-lysine methylation | protein ubiquitination | N-methyltransferase activity | metabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | peptidyl-lysine modification | nucleobase-containing compound metabolic process | organic substance metabolic process | histone lysine methylation | negative regulation of biosynthetic process | negative regulation of gene expression | gene expression | protein modification by small protein conjugation or removal | regulation of G0 to G1 transition | transcription, DNA-templated | negative regulation of cell cycle | histone ubiquitination | covalent chromatin modification | regulation of transcription, DNA-templated | protein-lysine N-methyltransferase activity | cellular protein metabolic process | cellular macromolecule biosynthetic process | protein methylation | regulation of developmental process | methyltransferase activity | organelle organization | cellular protein modification process | negative regulation of transcription by RNA polymerase II | heterocycle metabolic process | chromosome organization | cellular metabolic process | negative regulation of cell cycle process | negative regulation of cell differentiation | macromolecule metabolic process
GO Cellular Component
PcG protein complex | chromosome | RSC-type complex | intracellular membrane-bounded organelle | catalytic complex | cell | nuclear lumen | ESC/E(Z) complex | sex chromosome | nucleolus | sex chromatin | intracellular organelle | nuclear body | histone methyltransferase complex | protein-containing complex | methyltransferase complex | protein-DNA complex | nucleoplasm | chromatin | nuclear chromosome | transferase complex | membrane-bounded organelle | heterochromatin | nucleus | organelle | SWI/SNF superfamily-type complex | nuclear heterochromatin | membrane-enclosed lumen | nuclear chromatin | ATPase complex | intracellular
