QuickView for SYK;jsessionid=294EDDCCC7989D0B34A361E2CB0E8FAD (gene)
- Gene Symbol:
- SYK
Homo sapiens - Full name:
- spleen associated tyrosine kinase
- Synonyms:
- p72-Syk, tyrosine-protein kinase SYK, spleen tyrosine kinase
- Genomic Location:
- Chr 9: 92603891-92698305
- Description:
-
This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a mod...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Cytogenetic Map:
-
9q22.2
| Transcripts Names |
|---|
| NM_003177 |
| NM_001135052 |
| NR_024155 |
| NR_024156 |
| NM_001174167 |
| NM_001174168 |
| XR_001746370 |
| XM_005252147 |
| XM_011518946 |
GO Molecular Function
protein phosphorylated amino acid binding | kinase binding | protein kinase binding | enzyme binding | protein-containing complex binding | phosphotyrosine residue binding | ribonucleotide binding | nucleotide binding | signaling receptor binding | carbohydrate derivative binding | Toll-like receptor binding | protein serine/threonine kinase activity | catalytic activity | protein domain specific binding | ATP binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | ion binding | integrin binding | organic cyclic compound binding | cell adhesion molecule binding | purine ribonucleoside triphosphate binding | phosphoprotein binding | protein tyrosine kinase activity | protein binding | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | non-membrane spanning protein tyrosine kinase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | phosphatase binding | heterocyclic compound binding | small molecule binding | SH2 domain binding
GO Biological Process
positive regulation of immune response | regulation of JUN kinase activity | regulation of ERK1 and ERK2 cascade | adaptive immune response | interleukin-2-mediated signaling pathway | positive regulation of macromolecule biosynthetic process | exocytosis | leukotriene biosynthetic process | response to cytokine | leukotriene metabolic process | positive regulation of cellular component organization | regulation of B cell activation | cell motility | immune response-regulating signaling pathway | neutrophil activation | regulation of cellular localization | intracellular signal transduction | regulation of localization | cellular response to interleukin-2 | positive regulation of peptidyl-tyrosine phosphorylation | peptidyl-amino acid modification | defense response to other organism | establishment of localization | immune response-regulating cell surface receptor signaling pathway | regulation of immune system process | platelet degranulation | integrin-mediated signaling pathway | positive regulation of developmental process | regulation of MAP kinase activity | positive regulation of lymphocyte activation | cell differentiation | immune response-activating cell surface receptor signaling pathway | regulation of T cell differentiation | defense response | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | peptidyl-tyrosine phosphorylation | positive regulation of protein secretion | innate immune response activating cell surface receptor signaling pathway | intracellular transport | regulation of lipid transport | regulation of neutrophil degranulation | blood vessel morphogenesis | positive regulation of T cell differentiation | regulation of bone remodeling | innate immune response-activating signal transduction | positive regulation of cellular biosynthetic process | cellular process | production of molecular mediator involved in inflammatory response | secretion | Fc-gamma receptor signaling pathway involved in phagocytosis | lymphocyte differentiation | regulation of cytokine biosynthetic process | localization | interleukin-3-mediated signaling pathway | regulation of calcium-mediated signaling | protein transport | positive regulation of immune effector process | regulation of platelet aggregation | immune system development | positive regulation of protein kinase activity | macromolecule localization | regulation of response to cytokine stimulus | hemostasis | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | granulocyte chemotaxis | establishment of localization in cell | regulation of cell differentiation | cellular response to low-density lipoprotein particle stimulus | interspecies interaction between organisms | regulation of platelet activation | positive regulation of granulocyte macrophage colony-stimulating factor production | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of metabolic process | positive regulation of stress-activated MAPK cascade | protein import into nucleus | positive regulation of cellular protein metabolic process | positive regulation of cell adhesion mediated by integrin | icosanoid biosynthetic process | positive regulation of interleukin-4 production | regulation of mast cell degranulation | MAPK cascade | T cell activation | regulation of peptide secretion | regulation of type I interferon production | positive regulation of stress-activated protein kinase signaling cascade | response to stimulus | vasculature development | positive regulation of cold-induced thermogenesis | JNK cascade | positive regulation of innate immune response | neutrophil chemotaxis | regulation of peptidyl-tyrosine phosphorylation | serotonin secretion by platelet | positive regulation of immune system process | positive regulation of protein metabolic process | signal transduction by protein phosphorylation | response to stress | intracellular protein transport | leukocyte activation involved in immune response | regulation of receptor internalization | positive regulation of lymphocyte proliferation | regulation of cell proliferation | positive regulation of mast cell degranulation | tube morphogenesis | positive regulation of cell-cell adhesion | protein localization to nucleus | protein serine/threonine kinase activity | positive regulation of cytokine biosynthetic process | positive regulation of cell activation | activation of innate immune response | cellular localization | secretion by cell | organic hydroxy compound transport | positive regulation of cytokine secretion | cardiovascular system development | regulation of granulocyte macrophage colony-stimulating factor biosynthetic process | positive regulation of T cell activation | immune response-activating signal transduction | regulation of phagocytosis | regulation of protein transport | positive regulation of protein serine/threonine kinase activity | hemopoiesis | regulation of wound healing | protein modification process | regulation of peptide transport | regulation of cell adhesion | cellular biosynthetic process | macromolecule modification | positive regulation of B cell differentiation | cell chemotaxis | B cell receptor signaling pathway | activation of protein kinase activity | regulation of intracellular transport | regulation of lymphocyte differentiation | blood vessel development | stress-activated protein kinase signaling cascade | leukocyte migration | blood coagulation | regulation of nucleic acid-templated transcription | positive regulation of peptide secretion | leukocyte differentiation | positive regulation of exocytosis | regulation of cellular response to stress | locomotion | response to nitrogen compound | positive regulation of mononuclear cell proliferation | regulation of superoxide metabolic process | response to external biotic stimulus | system development | regulation of interleukin-4 production | nitrogen compound metabolic process | regulation of signal transduction | multicellular organism development | cell migration | positive regulation of lymphocyte differentiation | regulation of MAPK cascade | phosphorus metabolic process | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | lymph vessel development | regulation of phosphorylation | response to interleukin-2 | positive regulation of gamma-delta T cell differentiation | wound healing | Fc-gamma receptor signaling pathway | regulation of T cell activation | regulation of receptor-mediated endocytosis | positive regulation of receptor-mediated endocytosis | positive regulation of alpha-beta T cell differentiation | regulation of gene expression | platelet activation | positive regulation of secretion | organic substance transport | cellular response to stress | regulation of protein autophosphorylation | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | positive regulation of alpha-beta T cell proliferation | regulation of lymphocyte activation | animal organ morphogenesis | regulation of blood coagulation | regulation of mast cell activation | regulation of nitrogen compound metabolic process | enzyme linked receptor protein signaling pathway | positive regulation of JNK cascade | small molecule metabolic process | peptide transport | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | vesicle-mediated transport | alpha-beta T cell differentiation | protein localization to organelle | import into nucleus | Fc-epsilon receptor signaling pathway | positive regulation of cell differentiation | positive regulation of calcium-mediated signaling | macrophage activation involved in immune response | cellular response to cytokine stimulus | cell proliferation | biosynthetic process | positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process | stress-activated MAPK cascade | regulation of cellular protein metabolic process | positive regulation of T cell proliferation | regulation of gamma-delta T cell differentiation | angiogenesis | regulation of cell adhesion mediated by integrin | phosphorylation | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis | regulated exocytosis | positive regulation of peptidyl-tyrosine autophosphorylation | protein phosphorylation | phosphate-containing compound metabolic process | positive regulation of regulated secretory pathway | protein import | response to bacterium | response to fungus | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of alpha-beta T cell differentiation | receptor internalization | inflammatory response | regulation of tumor necrosis factor-mediated signaling pathway | cell activation involved in immune response | myeloid cell activation involved in immune response | regulation of protein metabolic process | positive regulation of signal transduction | neutrophil activation involved in immune response | leukocyte chemotaxis | defense response to bacterium | positive regulation of cell proliferation | positive regulation of establishment of protein localization | regulation of protein phosphorylation | serotonin transport | regulation of cytokine-mediated signaling pathway | regulation of RNA metabolic process | positive regulation of B cell activation | positive regulation of transport | viral process | coagulation | cellular response to lipoprotein particle stimulus | carboxylic acid metabolic process | lymphocyte activation | protein tyrosine kinase activity | positive regulation of molecular function | regulation of cytokine secretion | activation of MAPK activity | T cell differentiation | activation of immune response | response to molecule of fungal origin | protein metabolic process | regulation of establishment of protein localization | positive regulation of protein modification process | T cell selection | response to organic substance | regulation of innate immune response | regulation of homotypic cell-cell adhesion | regulation of hemopoiesis | regulation of kinase activity | response to wounding | import into cell | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | regulation of exocytosis | collagen-activated tyrosine kinase receptor signaling pathway | establishment of protein localization to organelle | anatomical structure development | cell surface receptor signaling pathway | leukocyte cell-cell adhesion | metabolic process | regulation of RNA biosynthetic process | positive regulation of leukocyte activation | regulation of body fluid levels | cellular protein localization | regulation of bone resorption | regulation of tissue remodeling | amide transport | regulation of vesicle-mediated transport | endocytosis | regulation of secretion | cell adhesion | regulation of arachidonic acid secretion | macrophage activation | immune response | protein kinase activity | positive regulation of mast cell activation | organic substance metabolic process | regulation of B cell differentiation | nuclear transport | beta selection | animal organ development | regulation of cell activation | regulation of protein secretion | positive regulation of kinase activity | alpha-beta T cell activation | regulation of phosphate metabolic process | antigen receptor-mediated signaling pathway | establishment of protein localization | cell-cell adhesion | positive regulation of cytokine production | regulation of regulated secretory pathway | positive regulation of intracellular transport | regulation of JNK cascade | positive regulation of interleukin-3 biosynthetic process | cell activation | positive regulation of MAPK cascade | collagen-activated signaling pathway | positive regulation of protein transport | anatomical structure formation involved in morphogenesis | icosanoid metabolic process | regulation of response to wounding | non-membrane spanning protein tyrosine kinase activity | regulation of stress-activated MAPK cascade | regulation of cell communication | signaling | regulation of transcription, DNA-templated | regulation of endocytosis | regulation of T cell proliferation | cellular response to molecule of fungal origin | protein localization | organic acid metabolic process | positive regulation of phosphorylation | cellular protein metabolic process | regulation of cytokine production | anatomical structure morphogenesis | cation transport | cellular macromolecule localization | positive regulation of MAP kinase activity | positive regulation of receptor internalization | response to biotic stimulus | nucleocytoplasmic transport | positive regulation of tissue remodeling | ammonium transport | regulation of developmental process | regulation of ion transport | receptor-mediated endocytosis | kinase activity | developmental process | positive regulation of alpha-beta T cell activation | Fc receptor signaling pathway | peptidyl-serine phosphorylation | cellular protein modification process | monoamine transport | positive regulation of protein autophosphorylation | Fc receptor mediated stimulatory signaling pathway | tube development | regulation of transport | regulation of reactive oxygen species metabolic process | regulation of cell-cell adhesion | regulation of superoxide anion generation | innate immune response | neurotransmitter transport | receptor metabolic process | regulation of fatty acid transport | positive regulation of bone resorption | serotonin secretion | response to organonitrogen compound | stimulatory C-type lectin receptor signaling pathway | regulation of anion transport | positive regulation of JUN kinase activity | transmembrane receptor protein tyrosine kinase signaling pathway | positive regulation of metabolic process | ion transport | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | cellular response to organic substance | regulation of protein localization | activation of JUN kinase activity | positive regulation of type I interferon production | neutrophil migration | circulatory system development | chemotaxis | phagocytosis | positive regulation of endocytosis | positive regulation of leukocyte cell-cell adhesion | regulation of cellular component organization | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gamma-delta T cell activation | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | T cell receptor complex | cytoplasmic vesicle | cell | plasma membrane protein complex | cytoplasm | intracellular organelle | receptor complex | protein-containing complex | plasma membrane | vesicle | membrane-bounded organelle | nucleus | organelle | cell periphery | B cell receptor complex | early phagosome | cytosol | intracellular vesicle | endocytic vesicle | intracellular | membrane | phagocytic vesicle
