QuickView for SYT1;jsessionid=E67AC4A221E7BD3706243AB3FA8CCE97 (gene)

Gene Symbol:

SYT1 Homo sapiens

Full name:

synaptotagmin 1

Synonyms:

P65, SVP65, SYT, synaptotagmin-1, synaptotagmin I, sytI

Genomic Location:

Chr 12: 78135414-78368974

Description:

The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001 [PubMed 11242035]).

The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001 [PubMed 11242035]).

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CACTGTG_MIR128A_MIR128B ,  ACAACTT_MIR382 ,  OCT1_05 ,  CACTGCC_MIR34A_MIR34C_MIR449 ,  TTTGCAC_MIR19A_MIR19B ,  AGTTCTC_MIR146A_MIR146B ,  OCT1_01 ,  YATGNWAAT_OCT_C ,  CTATGCA_MIR153 ,  TTTGTAG_MIR520D ,  YATTNATC_UNKNOWN ,  AAGCAAT_MIR137 ,  PBX1_01 ,  ACTGTGA_MIR27A_MIR27B ,  CDP_02 ,  CAGGTG_E12_Q6 ,  TGCACTG_MIR148A_MIR152_MIR148B ,  ATACCTC_MIR202 ,  GCAAAAA_MIR129 ,  FREAC2_01 ,  POU3F2_02 ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  TGCACTT_MIR519C_MIR519B_MIR519A ,  AGGCACT_MIR5153P ,  AGGAAGC_MIR5163P ,  TATTATA_MIR374

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-129 ,  Predicted Gene Targets for miR-133 ,  Predicted Gene Targets for miR-135 ,  Predicted Gene Targets for miR-146 ,  Predicted Gene Targets for miR-148 ,  Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-193 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-218 ,  Predicted Gene Targets for miR-221 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-329 ,  Predicted Gene Targets for miR-34 ,  Predicted Gene Targets for miR-369-3p ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-382 ,  Predicted Gene Targets for miR-450 ,  Predicted Gene Targets for miR-137 ,  Predicted Gene Targets for miR-374 ,  Predicted Gene Targets for miR-496

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Cytogenetic Map:

12q21.2

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