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QuickView for Salbutamol (compound)
PubChem
| Name: | Albuterol |
|---|---|
| PubChem Compound ID: | 11505167 |
| Description: | A short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared as a racemic mixture of R(-) and S(+) stereoisomers. The stereospecific preparation of R(-) isomer of albuterol is referred to as levalbuterol. |
| Molecular formula: | C26H44N2O10S |
| Molecular weight: | 576.701 g/mol |
DrugBank
Identification
| Name: | Albuterol |
|---|---|
| Name (isomeric): | DB01001 |
| Drug Type: | small molecule |
| Description: | A short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared as a racemic mixture of R(-) and S(+) stereoisomers. The stereospecific preparation of R(-) isomer of albuterol is referred to as levalbuterol. |
| Synonyms: |
Albuterol Sulphate; Albuterol Sulfate; Levalbuterol; Salbutamol Sulfate; Albuterol; Salbutamol Sulphate
|
| Brand: | Xopenex, Sultanol, Volmax, Cetsim, Aerolin, Ventolin HFA, Proventil, Asmaven, Asthavent, Cobutolin, Venetlin, Airomir, Asthalin, Accuneb, Salbulin, Buventol, Solbutamol, Salamol, Salbutard, Loftan, ProAir HFA, Ventalin Inhaler, Rotahaler, Volma, Salbutine, Xopenex HFA, Ventolin Inhaler, Ventolin Rotacaps, Broncovaleas, Salbuvent, Asmol, Proventil HFA, Ventolin, Ecovent, ProAir |
| Brand name mixture: | Gen-Combo Sterinebs(Ipratropium Bromide + Salbutamol Sulfate), Combivent(Ipratropium Bromide + Salbutamol Sulfate) |
| Category: | Tocolytic Agents, Adrenergic beta-Agonists, Bronchodilator Agents |
| CAS number: | 18559-94-9 |
Pharmacology
| Indication: | For symptomatic relief and prevention of bronchospasm due to bronchial asthma, chronic bronchitis, and other chronic bronchopulmonary disorders such as COPD. |
|---|---|
| Pharmacology: |
Salbutamol (INN) or albuterol (USAN), a moderately selective beta(2)-receptor agonist similar in structure to terbutaline, is widely used as a bronchodilator to manage asthma and other chronic obstructive airway diseases. The R-isomer, levalbuterol, is responsible for bronchodilation while the S-isomer increases bronchial reactivity. The R-enantio...
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| Mechanism of Action: |
Salbutamol is a beta(2)-adrenergic agonist and thus it stimulates beta(2)-adrenergic receptors. Binding of albuterol to beta(2)-receptors in the lungs results in relaxation of bronchial smooth muscles. It is believed that salbutamol increases cAMP production by activating adenylate cyclase, and the actions of salbutamol are mediated by cAMP. Increa...
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| Absorption: | Systemic absorption is rapid following aerosol administration. |
| Biotransformation: | Hydrolyzed by esterases in tissue and blood to the active compound colterol. The drug is also conjugatively metabolized to salbutamol 4'-O-sulfate. |
| Route of elimination: | Approximately 72% of the inhaled dose is excreted in the urine within 24 hours, 28% as unchanged drug and 44% as metabolite. |
| Half Life: | 1.6 hours |
| Toxicity: | LD50=1100 mg/kg (orally in mice) |
| Affected organisms: | Humans and other mammals |
Interactions
| Drug interaction: |
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Targets
Enzymes
