Name: | saxagliptin |
---|---|
PubChem Compound ID: | 11243969 |
Molecular formula: | C18H25N3O2 |
Molecular weight: | 315.41 g/mol |
Name: | saxagliptin |
---|---|
Name (isomeric): | DB06335 |
Drug Type: | small molecule |
Synonyms: |
BMS-477118; Onglyza
|
Brand: | Onglyza |
CAS number: | 361442-04-8 |
Indication: | Investigated for use/treatment in diabetes mellitus type 2.Z\ |
---|---|
Mechanism of Action: |
Saxagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor antidiabetic for the treatment of Type 2 diabetes. DPP-4 inhibitors are a class of compounds that work by affecting the action of natural hormones in the body called incretins. Incretins decrease blood sugar by increasing consumption of sugar by the body, mainly through increasing insulin pr...
show more » |
Absorption: | Following the 5 mg once daily dose, the median time to maximum concentration is 2 hours. |
Route of elimination: | Following a single 50 mg dose of 14C-saxagliptin, 24%, 36%, and 75% of the dose was excreted in the urine as saxagliptin, its active metabolite, and total radioactivity, respectively. A total of 22% of the administered radioactivity was recovered in feces representing the fraction of the saxagliptin dose excreted in bile and/or unabsorbed drug from the gastrointestinal tract. |
Half Life: | 2.5 hours |
Clearance: | Renal clearance = 230 mL/min |
Drug interaction: |
|
---|