QuickView for Sclerostin (gene)

Gene Symbol:

SOST Homo sapiens

Full name:

sclerostin

Synonyms:

CDD, DAND6, SOST1, VBCH, sclerostin

Genomic Location:

Chr 17: 39186625-39191682

Description:

Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteo...

View Full Description

Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Bos taurus ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

E12_Q6 ,  MYOD_Q6_01 ,  OCT1_05 ,  TGIF_01 ,  PU1_Q6 ,  TGANTCA_AP1_C ,  MYOD_01 ,  ETS_Q4 ,  AML_Q6 ,  HEN1_01 ,  GCANCTGNY_MYOD_Q6 ,  MEIS1BHOXA9_01 ,  MYAATNNNNNNNGGC_UNKNOWN ,  GGGYGTGNY_UNKNOWN ,  CAGGTA_AREB6_01 ,  ALPHACP1_01 ,  CAGGTG_E12_Q6 ,  AP4_Q6 ,  AP4_01 ,  MYOD_Q6 ,  MGGAAGTG_GABP_B ,  E47_01 ,  AAAGACA_MIR511 ,  NRF2_Q4 ,  OCT1_06 ,  RACCACAR_AML_Q6 ,  MEIS1AHOXA9_01 ,  ELK1_01 ,  TTGTTT_FOXO4_01 ,  WGGAATGY_TEF1_Q6 ,  MYOGENIN_Q6 ,  HEN1_02 ,  RGAGGAARY_PU1_Q6 ,  TGACAGNY_MEIS1_01 ,  CCANNAGRKGGC_UNKNOWN ,  CAGCTG_AP4_Q5 ,  AP4_Q5 ,  TCF1P_Q6 ,  ETS1_B ,  COREBINDINGFACTOR_Q6 ,  AAGCACA_MIR218

View More

View Less

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-218 ,  Predicted Gene Targets for miR-539

Cytogenetic Map:

17q21.31

search → result