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QuickView for Scn1a (gene)


Gene Symbol:
SCN1A Homo sapiens Homo sapiens
Full name:
sodium voltage-gated channel alpha subunit 1
Synonyms:
EIEE6, FEB3, FEB3A, FHM3, GEFSP2, HBSCI, NAC1, Nav1.1, SCN1, SMEI, sodium channel protein type 1 subunit alpha, sodium channel protein type I subunit alpha, sodium channel protein, brain I alpha subunit, sodium channel voltage gated type 1 alpha subunit, sodium channel, voltage-gated, type I, alpha polypeptide, sodium channel, voltage-gated, type I, alpha subunit, voltage-gated sodium channel subunit alpha Nav1.1
Genomic Location:
Chr 2: 166553916-166638395
Description:
Voltage-dependent sodium channels are heteromeric complexes that regulate sodium exchange between intracellular and extracellular spaces and are essential for the generation and propagation of action potentials in muscle cells and neurons. Each sodium channel is composed of a large pore-forming, glycosylated alpha subunit and two smaller beta subun...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Pan troglodytes Canis lupus familiaris Bos taurus Gallus gallus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 2
2q24.3





GO Molecular Function

voltage-gated ion channel activity | passive transmembrane transporter activity | voltage-gated sodium channel activity | transmembrane transporter activity | ion gated channel activity | cation transmembrane transporter activity | transporter activity | ion transmembrane transporter activity | metal ion transmembrane transporter activity | sodium ion transmembrane transporter activity | sodium channel activity | cation channel activity | inorganic cation transmembrane transporter activity | monovalent inorganic cation transmembrane transporter activity | voltage-gated channel activity | channel activity | ion channel activity | substrate-specific channel activity

GO Biological Process

heart process | actin filament-based process | detection of stimulus | regulation of localization | establishment of localization | detection of mechanical stimulus involved in sensory perception | membrane depolarization during action potential | voltage-gated ion channel activity | sensory perception of mechanical stimulus | cellular process | localization | passive transmembrane transporter activity | metal ion transport | walking behavior | actin filament-based movement | voltage-gated sodium channel activity | transmembrane transporter activity | heart contraction | actin-mediated cell contraction | muscle contraction | response to stimulus | ion gated channel activity | blood circulation | neuronal action potential | regulation of membrane potential | detection of abiotic stimulus | neuromuscular process controlling posture | ion transmembrane transport | detection of mechanical stimulus involved in sensory perception of pain | nervous system process | adult walking behavior | sodium ion transport | cation transmembrane transporter activity | monovalent inorganic cation transport | adult locomotory behavior | cardiac muscle cell action potential involved in contraction | ion transmembrane transporter activity | locomotory behavior | sensory perception of pain | cell communication | cardiac muscle cell contraction | striated muscle contraction | neuronal action potential propagation | cation transmembrane transport | response to mechanical stimulus | detection of stimulus involved in sensory perception | metal ion transmembrane transporter activity | behavior | membrane depolarization | sodium ion transmembrane transport | sodium ion transmembrane transporter activity | inorganic cation transmembrane transport | regulation of ion transmembrane transport | sodium channel activity | detection of mechanical stimulus | cation channel activity | adult behavior | sensory perception | transmembrane transport | action potential | signaling | inorganic cation transmembrane transporter activity | monovalent inorganic cation transmembrane transporter activity | neuromuscular process | voltage-gated channel activity | cation transport | channel activity | regulation of ion transport | regulation of transport | cardiac muscle cell action potential | transmission of nerve impulse | ion channel activity | ion transport | cardiac muscle contraction | substrate-specific channel activity | muscle system process | multicellular organismal process

GO Cellular Component

supramolecular fiber | intercalated disc | integral component of membrane | voltage-gated sodium channel complex | intracellular membrane-bounded organelle | sarcolemma | neuron projection | somatodendritic compartment | sarcomere | cell body | cell | nuclear lumen | neuronal cell body | plasma membrane protein complex | intrinsic component of membrane | myofibril | cytoplasm | intracellular organelle | nuclear body | contractile fiber | axon initial segment | main axon | cell-cell junction | cell-cell contact zone | protein-containing complex | cell projection | nucleoplasm | plasma membrane | node of Ranvier | integral component of plasma membrane | T-tubule | membrane-bounded organelle | nucleus | organelle | I band | sodium channel complex | cell periphery | axon | membrane-enclosed lumen | transmembrane transporter complex | cation channel complex | ion channel complex | Z disc | intracellular | cell junction | membrane | supramolecular complex | intrinsic component of plasma membrane