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QuickView for Scopolamine (compound)

Summary
General Info

DrugBank

Identification

Name:	Scopolamine
Name (isomeric):	DB00747
Drug Type:	small molecule
Brand:	Hyoscyine Hydrobromide, Hyoscine Bromide, Scopolaminium Bromide, Atroscine Hydrobromide, Transderm-V, Isoscopil, Sereen, Scopamin, Skopolamin, Scopolamine Hydrobromide, Tranaxine, Hyosol, Scopolamine Bromide, Scopolamine Hyoscine, Atroquin, Scopos, Scopolammonium Bromide, Hyocine F Hydrobromide, Scopolamine Hydrobromide Trihydrate, Scopine Tropate, Hyoscine, Epoxytropine Tropate, Transcop, Transderm-Scop, Beldavrin, Atrochin, Triptone, Hyosceine, SEE, Methscopolamine Bromide, Isopto Hyoscine, Tropic Acid, Ester with Scopine, L-Hyoscine Hydrobromide, Hyoscine Hydrobromide, Hysco, Scopoderm-Tts, L-Scopolamine, Hydroscine Hydrobromide, Buscopan, Kwells, Scopolaminhydrobromid, Euscopol, Oscine, Scop
Category:	Muscarinic Antagonists, Adjuvants, Anesthesia, Mydriatics, Cholinergic Antagonists, Antispasmodics, Adjuvants, Antimuscarinics
CAS number:	6533-68-2

Pharmacology

Indication:	For the treatment of excessive salivation, colicky abdominal pain, bradycardia, sialorrhoea, diverticulitis, irritable bowel syndrome and motion sickness.
Pharmacology:	Scopolamine is a muscarinic antagonist structurally similar to the neurotransmitter acetylcholine and acts by blocking the muscarinic acetylcholine receptors and is thus classified as an anticholinergic. Scopolamine has many uses including the prevention of motion sickness. It is not clear how Scopolamine prevents nausea and vomiting due to motion ... show more » Scopolamine is a muscarinic antagonist structurally similar to the neurotransmitter acetylcholine and acts by blocking the muscarinic acetylcholine receptors and is thus classified as an anticholinergic. Scopolamine has many uses including the prevention of motion sickness. It is not clear how Scopolamine prevents nausea and vomiting due to motion sickness. The vestibular part of the ear is very important for balance. When a person becomes disoriented due to motion, the vestibule sends a signal through nerves to the vomiting center in the brain, and vomiting occurs. Acetylcholine is a chemical that nerves use to transmit messages to each other. It is believe that Scopolamine prevents communication between the nerves of the vestibule and the vomiting center in the brain by blocking the action of acetylcholine. Scopolamine also may work directly on the vomiting center. Scopolamine must be taken before the onset of motion sickness to be effective. show less «
Mechanism of Action:	Scopolamine acts by interfering with the transmission of nerve impulses by acetylcholine in the parasympathetic nervous system (specifically the vomiting center).
Route of elimination:	Less than 10% of the total dose is excreted in the urine as parent and metabolites over 108 hours.
Affected organisms:	Humans and other mammals

Interactions

Drug interaction:

Trimethobenzamide	Trimethobenzamide and Scopolamine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Donepezil	Possible antagonism of action
Tacrine	The therapeutic effects of the central acetylcholinesterase inhibitor, Tacrine, and/or the anticholinergic, Scopolamine, may be reduced due to antagonism. The interaction may be beneficial when the anticholinergic action is a side effect. Monitor for decreased efficacy of both agents.
Triprolidine	Triprolidine and Scopolamine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Additive CNS depressant effects may also occur. Monitor for enhanced anticholinergic and CNS depressant effects.
Cinitapride	Anticholinergic agents like scopolamine may reduce the action of cinitapride.

Targets

Muscarinic acetylcholine receptor M1

Sucrase-isomaltase, intestinal

Muscarinic acetylcholine receptor M2

Muscarinic acetylcholine receptor M3

Muscarinic acetylcholine receptor M4

Muscarinic acetylcholine receptor M5

Transporters

Multidrug resistance protein 1