QuickView for Sema3a (gene)

Gene Symbol:

SEMA3A Homo sapiens

Full name:

semaphorin 3A

Synonyms:

COLL1, HH16, Hsema-I, Hsema-III, SEMA1, SEMAD, SEMAIII, SEMAL, SemD, coll-1, semaphorin-3A, collapsin 1, sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A, semaphorin D, semaphorin III, semaphorin L

Genomic Location:

Chr 7: 83425595-83662153

Description:

This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the pro...

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This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NFAT_Q4_01 ,  TGGAAA_NFAT_Q4_01 ,  PR_Q2 ,  PR_02 ,  HNF1_01 ,  TTANTCA_UNKNOWN ,  FOXJ2_02 ,  AREB6_02 ,  SYATTGTG_UNKNOWN ,  AAAYWAACM_HFH4_01 ,  CIZ_01 ,  YATTNATC_UNKNOWN ,  AACTGGA_MIR145 ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  AMEF2_Q6 ,  FAC1_01 ,  CTTTGA_LEF1_Q2 ,  RYCACNNRNNRNCAG_UNKNOWN ,  WTGAAAT_UNKNOWN ,  TATAAA_TATA_01 ,  CEBPDELTA_Q6 ,  RGAANNTTC_HSF1_01 ,  PAX4_02 ,  FOXO3_01 ,  GGATTA_PITX2_Q2 ,  CEBP_01 ,  CAGGTG_E12_Q6 ,  TTCYRGAA_UNKNOWN ,  TATA_C ,  OCT1_03 ,  S8_01 ,  IRF_Q6 ,  CTTTAAR_UNKNOWN ,  TGTTTGY_HNF3_Q6 ,  SOX5_01 ,  OCT1_02 ,  MTF1_Q4 ,  POU3F2_02 ,  TAATTA_CHX10_01 ,  TTGTTT_FOXO4_01 ,  GR_01 ,  PIT1_Q6 ,  GATA4_Q3 ,  WTTGKCTG_UNKNOWN ,  IK3_01 ,  YTAATTAA_LHX3_01 ,  PAX_Q6 ,  RORA2_01 ,  GRE_C ,  CTTTGT_LEF1_Q2 ,  PAX3_B ,  MMEF2_Q6 ,  FOXM1_01 ,  AACTTT_UNKNOWN ,  YNGTTNNNATT_UNKNOWN ,  USF_02 ,  TCF1P_Q6 ,  PPARA_02 ,  HNF1_Q6 ,  HNF6_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-145 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-33 ,  Predicted Gene Targets for miR-365

Cytogenetic Map:

7q21.11

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