QuickView for Sema7A (gene)

Gene Symbol:

SEMA7A Homo sapiens

Full name:

semaphorin 7A (John Milton Hagen blood group)

Synonyms:

CD108, CDw108, H-SEMA-K1, H-Sema-L, JMH, SEMAK1, SEMAL, semaphorin-7A, JMH blood group antigen, John Milton Hagen blood group H-Sema K1, john-Milton-Hargen human blood group Ag, sema K1, sema L, sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A (JMH blood group), sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, 7A, semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group), semaphorin-K1, semaphorin-L

Genomic Location:

Chr 15: 72489376-72513329

Description:

This gene encodes a member of the semaphorin family of proteins. The encoded preproprotein is proteolytically processed to generate the mature glycosylphosphatidylinositol (GPI)-anchored membrane glycoprotein. The encoded protein is found on activated lymphocytes and erythrocytes and may be involved in immunomodulatory and neuronal processes. The e...

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This gene encodes a member of the semaphorin family of proteins. The encoded preproprotein is proteolytically processed to generate the mature glycosylphosphatidylinositol (GPI)-anchored membrane glycoprotein. The encoded protein is found on activated lymphocytes and erythrocytes and may be involved in immunomodulatory and neuronal processes. The encoded protein carries the John Milton Hagen (JMH) blood group antigens. Mutations in this gene may be associated with reduced bone mineral density (BMD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  IRF1_01 ,  OCT1_05 ,  TGIF_01 ,  YATGNWAAT_OCT_C ,  CACGTG_MYC_Q2 ,  ZF5_01 ,  TAAYNRNNTCC_UNKNOWN ,  MYB_Q5_01 ,  MYCMAX_B ,  OCT_C ,  TGACCTY_ERR1_Q2 ,  HEB_Q6 ,  GGGAGGRR_MAZ_Q6 ,  MYCMAX_02 ,  CAGGTA_AREB6_01 ,  P53_02 ,  AP4_01 ,  YGCANTGCR_UNKNOWN ,  GGGCGGR_SP1_Q6 ,  USF_C ,  LMO2COM_02 ,  RAAGNYNNCTTY_UNKNOWN ,  CTTTAAR_UNKNOWN ,  MYB_Q6 ,  NMYC_01 ,  TAATTA_CHX10_01 ,  CEBP_C ,  PIT1_Q6 ,  MEF2_03 ,  CTTTGT_LEF1_Q2 ,  CAGCTG_AP4_Q5 ,  ERR1_Q2 ,  TCF1P_Q6 ,  TGACCTTG_SF1_Q6 ,  GGGTGGRR_PAX4_03 ,  SF1_Q6 ,  MYB_Q3

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Cytogenetic Map:

15q24.1

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