Name: | sertindole |
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PubChem Compound ID: | 475096 |
Molecular formula: | C24H26ClFN4O |
Molecular weight: | 440.941 g/mol |
Synonyms: |
Lu 23-174; AIDS-085405; AIDS085405; 106516-24-9; 2-Imidazolidinone, 1-[2-[4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl]-1-piperidinyl]ethyl]; 1-[2-[4-[5-Chloro-1-(p-fluorophenyl)indol-3-yl]piperidino]ethyl]-2-imidazolidinone; Sertindole
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Name: | sertindole |
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Name (isomeric): | DB06144 |
Drug Type: | small molecule |
Synonyms: |
Sertindol [inn-spanish]; Sertindolum [inn-latin]
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Brand: | Serlect, Serdolect |
Category: | Neuroleptics, Antipsychotic Agents |
CAS number: | 106516-24-9 |
Indication: | Used in the treatment of schizophrenia. |
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Pharmacology: |
Sertindole is an atypical antipsychotic at least as effective as haloperidol and risperidone in the treatment of neuroleptic-responsive schizophrenia. Sertindole improves negative symptoms, and is also effective for the treatment of neuroleptic-resistant schizophrenia. Sertindole is generally well tolerated and is associated with a low rate of extr...
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Mechanism of Action: | Sertindole is an antipsychotic drug with affinity for dopamine D2, serotonin 5-HT2A and 5-HT2C, and alpha1-adrenoreceptors. Preclinical studies suggest that sertindole acts preferentially on limbic and cortical dopaminergic neurons and clinical trials have confirmed that sertindole is effective at a low dopamine D2 occupancy level. |
Absorption: | Orally available. |
Biotransformation: | Hepatic. Sertindole is metabolized by cytochrome P450 isoenzymes CYP 2D6 and CYP 3A4. |
Half Life: | 3 days |
Affected organisms: | Humans and other mammals |
Drug interaction: |
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