QuickView for Shh (gene)

Gene Symbol:

SHH Homo sapiens

Full name:

sonic hedgehog

Synonyms:

HHG1, HLP3, HPE3, MCOPCB5, SMMCI, ShhNC, TPT, TPTPS, sonic hedgehog protein, shh unprocessed N-terminal signaling and C-terminal autoprocessing domains, sonic hedgehog homolog

Genomic Location:

Chr 7: 155288319-155297728

Description:

This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this ...

View Full Description

This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

PR_Q2 ,  GATTGGY_NFY_Q6_01 ,  SMTTTTGT_UNKNOWN ,  AREB6_02 ,  YTATTTTNR_MEF2_02 ,  NFY_C ,  GGGAGGRR_MAZ_Q6 ,  AR_Q6 ,  CACCCBINDINGFACTOR_Q6 ,  NFY_Q6_01 ,  CAGGTG_E12_Q6 ,  AREB6_01 ,  NFY_Q6 ,  CTTTAAR_UNKNOWN ,  SPZ1_01 ,  GCCNNNWTAAR_UNKNOWN ,  RORA1_01 ,  RNGTGGGC_UNKNOWN ,  POU3F2_02 ,  YGCGYRCGC_UNKNOWN ,  GTGGGTGK_UNKNOWN ,  T3R_Q6 ,  RORA2_01 ,  CTTTGT_LEF1_Q2 ,  ER_Q6_01 ,  CDC5_01 ,  BRN2_01 ,  GGGTGGRR_PAX4_03

View More

View Less

Cytogenetic Map:

7q36.3

search → result