QuickView for Skp2 (gene)

Gene Symbol:

SKP2 Homo sapiens

Full name:

S-phase kinase associated protein 2

Synonyms:

FBL1, FBXL1, FLB1, p45, S-phase kinase-associated protein 2, CDK2/cyclin A-associated protein p45, F-box/LRR-repeat protein 1, S-phase kinase-associated protein 2, E3 ubiquitin protein ligase, p45skp2

Genomic Location:

Chr 5: 36187946-36219904

Description:

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into ...

View Full Description

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  YTCCCRNNAGGY_UNKNOWN ,  STAT1_02 ,  AAANWWTGC_UNKNOWN ,  STAT1_03 ,  E2F1_Q4 ,  AR_Q6 ,  CEBP_Q2 ,  CAGGTG_E12_Q6 ,  AACYNNNNTTCCS_UNKNOWN ,  YKACATTT_UNKNOWN ,  ACTAYRNNNCCCR_UNKNOWN ,  YGCGYRCGC_UNKNOWN ,  SCGGAAGY_ELK1_02 ,  TGACATY_UNKNOWN

View More

View Less

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-338

Cytogenetic Map:

5p13.2

search → result