QuickView for Slc12a2 (gene)

Gene Symbol:

SLC12A2 Homo sapiens

Full name:

solute carrier family 12 member 2

Synonyms:

BSC, BSC2, NKCC1, PPP1R141, solute carrier family 12 member 2, basolateral Na-K-Cl symporter, bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1, protein phosphatase 1, regulatory subunit 141, solute carrier family 12 (sodium/potassium/chloride transporter), member 2, solute carrier family 12 (sodium/potassium/chloride transporters), member 2

Genomic Location:

Chr 5: 127447382-127553279

Description:

The protein encoded by this gene mediates sodium and chloride transport and reabsorption. The encoded protein is a membrane protein and is important in maintaining proper ionic balance and cell volume. This protein is phosphorylated in response to DNA damage. Three transcript variants encoding two different isoforms have been found for this gene.

The protein encoded by this gene mediates sodium and chloride transport and reabsorption. The encoded protein is a membrane protein and is important in maintaining proper ionic balance and cell volume. This protein is phosphorylated in response to DNA damage. Three transcript variants encoding two different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Gallus gallus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGIF_01 ,  GTGTTGA_MIR505 ,  TMTCGCGANR_UNKNOWN ,  NFKAPPAB_01 ,  TACTTGA_MIR26A_MIR26B ,  HNF1_C ,  TTTNNANAGCYR_UNKNOWN ,  NFKAPPAB65_01 ,  CATTTCA_MIR203 ,  TATA_C ,  GGGCGGR_SP1_Q6 ,  AAGGGAT_MIR188 ,  ATACTGT_MIR144 ,  GTGCCTT_MIR506 ,  SCGGAAGY_ELK1_02 ,  RGTTAMWNATT_HNF1_01 ,  GTGGGTGK_UNKNOWN ,  CREL_01 ,  TGACAGNY_MEIS1_01 ,  CAGCTG_AP4_Q5 ,  AACTTT_UNKNOWN ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  HNF1_Q6 ,  HNF6_Q6 ,  GGGNNTTTCC_NFKB_Q6_01 ,  AAGCACA_MIR218

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-218 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-329 ,  Predicted Gene Targets for miR-34 ,  Predicted Gene Targets for miR-503 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-137 ,  Predicted Gene Targets for miR-188 ,  Predicted Gene Targets for miR-203 ,  Predicted Gene Targets for miR-374 ,  Predicted Gene Targets for miR-505 ,  Predicted Gene Targets for miR-378

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Cytogenetic Map:

5q23.3

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