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QuickView for Slc4a4 (gene)


Gene Symbol:
SLC4A4 Homo sapiens Homo sapiens
Full name:
solute carrier family 4 member 4
Synonyms:
HNBC1, KNBC, NBC1, NBC2, NBCe1-A, SLC4A5, hhNMC, kNBC1, pNBC, electrogenic sodium bicarbonate cotransporter 1, Na(+)/HCO3(-) cotransporter, sodium bicarbonate cotransporter 1 (sodium bicarbonate cotransporter, kidney; sodium bicarbonate cotransporter, pancreas), solute carrier family 4 (sodium bicarbonate cotransporter), member 4, solute carrier family 4, sodium bicarbonate cotransporter, member 4, brain type, solute carrier family 4, sodium bicarbonate cotransporter, member 5
Genomic Location:
Chr 4: 72271867-72656663
Description:
This gene encodes a sodium bicarbonate cotransporter (NBC) involved in the regulation of bicarbonate secretion and absorption and intracellular pH. Mutations in this gene are associated with proximal renal tubular acidosis. Multiple transcript variants encoding different isoforms have been found for this gene.
Orthologs:
Mus musculus Rattus norvegicus Saccharomyces cerevisiae Macaca mulatta Schizosaccharomyces pombe Bos taurus Gallus gallus Pan troglodytes Canis lupus familiaris Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Predicted Gene Targets for let-7 Predicted Gene Targets for miR-101 Predicted Gene Targets for miR-125 Predicted Gene Targets for miR-142-5p Predicted Gene Targets for miR-144 Predicted Gene Targets for miR-145 Predicted Gene Targets for miR-15 Predicted Gene Targets for miR-153 Predicted Gene Targets for miR-204 Predicted Gene Targets for miR-214
Cytogenetic Map:
chr 4
4q13.3





GO Molecular Function

inorganic anion exchanger activity | organic anion transmembrane transporter activity | anion transmembrane transporter activity | sodium:bicarbonate symporter activity | transmembrane transporter activity | inorganic anion transmembrane transporter activity | symporter activity | bicarbonate transmembrane transporter activity | cation transmembrane transporter activity | active transmembrane transporter activity | transporter activity | ion transmembrane transporter activity | protein binding | metal ion transmembrane transporter activity | sodium ion transmembrane transporter activity | secondary active transmembrane transporter activity | inorganic cation transmembrane transporter activity | monovalent inorganic cation transmembrane transporter activity | solute:sodium symporter activity

GO Biological Process

inorganic anion exchanger activity | organic anion transmembrane transporter activity | establishment of localization | anion transmembrane transporter activity | cellular chemical homeostasis | cellular process | localization | cellular homeostasis | metal ion transport | anion transport | sodium:bicarbonate symporter activity | transmembrane transporter activity | inorganic anion transport | inorganic anion transmembrane transporter activity | symporter activity | ion transmembrane transport | bicarbonate transmembrane transporter activity | organic substance transport | sodium ion transport | cation transmembrane transporter activity | cellular ion homeostasis | monovalent inorganic cation transport | active transmembrane transporter activity | ion transmembrane transporter activity | bicarbonate transport | organic anion transport | cation homeostasis | cellular cation homeostasis | regulation of intracellular pH | homeostatic process | cation transmembrane transport | regulation of pH | metal ion transmembrane transporter activity | anion transmembrane transport | chemical homeostasis | sodium ion transmembrane transport | ion homeostasis | sodium ion transmembrane transporter activity | inorganic cation transmembrane transport | secondary active transmembrane transporter activity | regulation of cellular pH | transmembrane transport | inorganic cation transmembrane transporter activity | cellular monovalent inorganic cation homeostasis | monovalent inorganic cation transmembrane transporter activity | cation transport | ion transport | solute:sodium symporter activity

GO Cellular Component

integral component of membrane | cell | intrinsic component of membrane | plasma membrane | vesicle | extracellular exosome | integral component of plasma membrane | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | extracellular space | cell periphery | basolateral plasma membrane | membrane | intrinsic component of plasma membrane