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QuickView for Slc9a3 (gene)


Gene Symbol:
SLC9A3 Homo sapiens Homo sapiens
Full name:
solute carrier family 9 member A3
Synonyms:
DIAR8, NHE-3, NHE3, sodium/hydrogen exchanger 3, Na(+)/H(+) exchanger 3, solute carrier family 9 (sodium/hydrogen exchanger), solute carrier family 9 (sodium/hydrogen exchanger), member 3, solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
Genomic Location:
Chr 5: 526425-577447
Description:
The protein encoded by this gene is an epithelial brush border Na/H exchanger that uses an inward sodium ion gradient to expel acids from the cell. Defects in this gene are a cause of congenital secretory sodium diarrhea. Pseudogenes of this gene exist on chromosomes 10 and 22.
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster Macaca mulatta Bos taurus Gallus gallus Danio rerio Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 5
5p15.33


Transcripts Names
NM_004174
NM_001284351
Protein Names
Q3MIW3
P48764



GO Molecular Function

monovalent cation:proton antiporter activity | proton transmembrane transporter activity | transmembrane transporter activity | protein domain specific binding | potassium:proton antiporter activity | cation transmembrane transporter activity | potassium ion antiporter activity | antiporter activity | active transmembrane transporter activity | transporter activity | ion transmembrane transporter activity | cation:cation antiporter activity | protein binding | metal ion transmembrane transporter activity | potassium ion transmembrane transporter activity | sodium:proton antiporter activity | sodium ion transmembrane transporter activity | secondary active transmembrane transporter activity | solute:proton antiporter activity | inorganic cation transmembrane transporter activity | monovalent inorganic cation transmembrane transporter activity | PDZ domain binding

GO Biological Process

monovalent cation:proton antiporter activity | establishment of localization | proton transmembrane transporter activity | cellular chemical homeostasis | cellular process | proton transmembrane transport | localization | cellular homeostasis | metal ion transport | transmembrane transporter activity | potassium:proton antiporter activity | ion transmembrane transport | sodium ion transport | cation transmembrane transporter activity | potassium ion antiporter activity | cellular ion homeostasis | monovalent inorganic cation transport | antiporter activity | active transmembrane transporter activity | cellular potassium ion transport | ion transmembrane transporter activity | potassium ion transport | cation:cation antiporter activity | cation homeostasis | cellular cation homeostasis | regulation of intracellular pH | homeostatic process | cation transmembrane transport | regulation of pH | import into cell | metal ion transmembrane transporter activity | potassium ion transmembrane transporter activity | sodium:proton antiporter activity | chemical homeostasis | sodium ion import across plasma membrane | sodium ion transmembrane transport | ion homeostasis | sodium ion transmembrane transporter activity | inorganic cation transmembrane transport | secondary active transmembrane transporter activity | solute:proton antiporter activity | regulation of cellular pH | transmembrane transport | inorganic cation transmembrane transporter activity | cellular monovalent inorganic cation homeostasis | monovalent inorganic cation transmembrane transporter activity | cation transport | inorganic cation import across plasma membrane | potassium ion transmembrane transport | ion transport

GO Cellular Component

brush border | integral component of membrane | apical plasma membrane | cell projection membrane | cell | intrinsic component of membrane | brush border membrane | apical part of cell | cell projection | plasma membrane | vesicle | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | extracellular space | cell periphery | cell surface | membrane