QuickView for Slx4 (gene)
- Gene Symbol:
- SLX4
Homo sapiens - Full name:
- SLX4 structure-specific endonuclease subunit
- Synonyms:
- BTBD12, FANCP, MUS312, structure-specific endonuclease subunit SLX4, BTB/POZ domain-containing protein 12
- Genomic Location:
- Chr 16: 3571183-3601586
- Description:
-
This gene encodes a protein that functions as an assembly component of multiple structure-specific endonucleases. These endonuclease complexes are required for repair of specific types of DNA lesions and critical for cellular responses to replication fork failure. Mutations in this gene were found in patients with Fanconi anemia.
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
16p13.3
GO Molecular Function
enzyme activator activity | nuclease activity | 5'-flap endonuclease activity | hydrolase activity | flap endonuclease activity | molecular function regulator | catalytic activity | deoxyribonuclease activity | hydrolase activity, acting on ester bonds | crossover junction endodeoxyribonuclease activity | 3'-flap endonuclease activity | endodeoxyribonuclease activity, producing 5'-phosphomonoesters | endodeoxyribonuclease activity | protein binding | endodeoxyribonuclease activity, producing 3'-phosphomonoesters | endonuclease activity | endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters | enzyme regulator activity
GO Biological Process
interstrand cross-link repair | double-strand break repair | telomere maintenance | positive regulation of cellular component organization | enzyme activator activity | nuclease activity | negative regulation of cellular process | response to DNA damage checkpoint signaling | regulation of organelle organization | negative regulation of DNA metabolic process | cellular process | positive regulation of t-circle formation | resolution of meiotic recombination intermediates | 5'-flap endonuclease activity | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | anatomical structure homeostasis | t-circle formation | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | DNA double-strand break processing involved in repair via single-strand annealing | cellular aromatic compound metabolic process | cellular component organization | response to stimulus | chromosome segregation | telomeric loop disassembly | response to stress | reproduction | cellular nitrogen compound metabolic process | telomere organization | nucleic acid phosphodiester bond hydrolysis | negative regulation of metabolic process | cellular component assembly | cellular biosynthetic process | DNA recombination | flap endonuclease activity | meiotic chromosome segregation | molecular function regulator | DNA repair | meiotic chromosome separation | nitrogen compound metabolic process | reproductive process | positive regulation of organelle organization | double-strand break repair via homologous recombination | cellular response to DNA damage stimulus | regulation of telomere maintenance | regulation of catalytic activity | positive regulation of chromosome organization | cellular response to stress | DNA double-strand break processing | cell cycle | positive regulation of cellular metabolic process | deoxyribonuclease activity | regulation of nitrogen compound metabolic process | crossover junction endodeoxyribonuclease activity | biosynthetic process | 3'-flap endonuclease activity | response to intra-S DNA damage checkpoint signaling | nuclear chromosome segregation | regulation of telomere maintenance via telomere lengthening | endodeoxyribonuclease activity, producing 5'-phosphomonoesters | regulation of cellular metabolic process | endodeoxyribonuclease activity | homeostatic process | telomeric D-loop disassembly | negative regulation of telomere maintenance | positive regulation of molecular function | DNA metabolic process | reciprocal meiotic recombination | nuclear division | metabolic process | nucleotide-excision repair | double-strand break repair via single-strand annealing | endodeoxyribonuclease activity, producing 3'-phosphomonoesters | nucleobase-containing compound metabolic process | positive regulation of cellular component biogenesis | organic substance metabolic process | endonuclease activity | regulation of chromosome organization | meiosis I | endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters | meiotic cell cycle | negative regulation of chromosome organization | negative regulation of telomere maintenance via telomere lengthening | enzyme regulator activity | telomere maintenance via telomere trimming | cellular macromolecule biosynthetic process | homologous recombination | response to biotic stimulus | positive regulation of telomere maintenance | positive regulation of DNA metabolic process | recombinational repair | organelle organization | heterocycle metabolic process | positive regulation of metabolic process | chromosome organization | meiotic DNA double-strand break processing | cellular metabolic process | chromosome separation | DNA replication | regulation of cellular component organization | macromolecule metabolic process
GO Cellular Component
chromosome | intracellular membrane-bounded organelle | DNA repair complex | cell | nuclear lumen | cytoplasm | Holliday junction resolvase complex | intracellular organelle | protein-containing complex | nucleotide-excision repair complex | nucleoplasm | chromatin | nuclear chromosome | ERCC4-ERCC1 complex | chromosome, telomeric region | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | nuclear chromatin | Slx1-Slx4 complex | cytosol | nuclear chromosome, telomeric region | intracellular | cell junction
