QuickView for Smad3 (gene)
- Gene Symbol:
- SMAD3
Homo sapiens - Full name:
- SMAD family member 3
- Synonyms:
- HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3, mothers against decapentaplegic homolog 3, MAD homolog 3, MAD, mothers against decapentaplegic homolog 3, SMA- and MAD-related protein 3, SMAD, mothers against DPP homolog 3, hMAD-3, hSMAD3, mad homolog JV15-2, mad protein homolog, mad3, mothers against DPP homolog 3
- Genomic Location:
- Chr 15: 65145249-65274587
- Description:
-
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional ...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , Macaca mulatta , Danio rerio , Gallus gallus , Bos taurus , Canis lupus familiaris , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
15q22.33
GO Molecular Function
sequence-specific DNA binding | beta-catenin binding | kinase binding | transcription regulatory region DNA binding | transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity | RNA polymerase II transcription factor activity, sequence-specific DNA binding | enhancer binding | cation binding | hormone receptor binding | protein kinase binding | proximal promoter sequence-specific DNA binding | mineralocorticoid receptor binding | enzyme binding | RNA polymerase II activating transcription factor binding | nucleic acid binding | protein-containing complex binding | transforming growth factor beta receptor binding | DEAD/H-box RNA helicase binding | signaling receptor binding | cytokine receptor binding | ubiquitin binding | chromatin binding | co-SMAD binding | ubiquitin-like protein ligase binding | collagen binding | RNA polymerase II regulatory region DNA binding | bHLH transcription factor binding | DNA binding | sequence-specific double-stranded DNA binding | identical protein binding | nuclear hormone receptor binding | protein heterodimerization activity | ubiquitin-like protein binding | primary miRNA binding | ion binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | protein homodimerization activity | zinc ion binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | transcription factor binding | chromatin DNA binding | ubiquitin protein ligase binding | RNA polymerase II transcription factor binding | activating transcription factor binding | protein dimerization activity | RNA polymerase II regulatory region sequence-specific DNA binding | transition metal ion binding | transforming growth factor beta receptor, cytoplasmic mediator activity | steroid hormone receptor binding | phosphatase binding | transcription coregulator activity | SMAD binding | metal ion binding | transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding | glucocorticoid receptor binding | heterocyclic compound binding | R-SMAD binding | RNA binding
GO Biological Process
protein modification by small protein removal | RNA metabolic process | transcription by RNA polymerase II | signal transduction involved in regulation of gene expression | gene silencing by RNA | regulation of supramolecular fiber organization | regulation of interleukin-1 beta production | SMAD protein signal transduction | regulation of muscle system process | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | regulation of cysteine-type endopeptidase activity | regulation of dephosphorylation | regulation of intracellular protein transport | response to cytokine | RNA processing | positive regulation of cellular component organization | positive regulation of adherens junction organization | cranial skeletal system development | regulation of cellular localization | positive regulation of apoptotic process | proteolysis | protein stabilization | regulation of localization | morphogenesis of an epithelium | positive regulation of DNA-binding transcription factor activity | regulation of programmed cell death | foregut morphogenesis | eye development | paraxial mesoderm morphogenesis | regulation of osteoblast proliferation | regulation of immune system process | regulation of nitric oxide biosynthetic process | regulation of transforming growth factor beta receptor signaling pathway | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | positive regulation of developmental process | regulation of phosphatase activity | negative regulation of RNA biosynthetic process | regulation of protein import | cell differentiation | negative regulation of fat cell differentiation | positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway | regulation of extracellular matrix organization | cellular chemical homeostasis | positive regulation of biomineral tissue development | production of small RNA involved in gene silencing by RNA | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | regulation of organelle organization | positive regulation of cellular component movement | mesenchyme development | pattern specification process | positive regulation of dephosphorylation | positive regulation of cellular biosynthetic process | cellular process | regulation of gene expression, epigenetic | evasion or tolerance of host defenses by virus | negative regulation of inflammatory response | positive regulation of cartilage development | regulation of cell motility | cellular homeostasis | epithelial tube morphogenesis | extrinsic apoptotic signaling pathway | mesoderm morphogenesis | heart morphogenesis | negative regulation of signaling | developmental growth | positive regulation of reactive oxygen species metabolic process | determination of left/right symmetry | dsRNA fragmentation | canonical Wnt signaling pathway | positive regulation of epithelial to mesenchymal transition | mesoderm development | immune system development | negative regulation of nucleic acid-templated transcription | regulation of striated muscle tissue development | regulation of chemotaxis | negative regulation of apoptotic process | digestive tract morphogenesis | response to hypoxia | regulation of proteolysis | osteoblast development | regulation of cell cycle | response to growth factor | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | regulation of canonical Wnt signaling pathway | negative regulation of cellular metabolic process | regulation of bone mineralization | positive regulation of chondrocyte differentiation | tissue development | regulation of binding | regulation of fat cell differentiation | regulation of cell differentiation | interspecies interaction between organisms | negative regulation of wound healing | negative regulation of muscle hypertrophy | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of osteoblast differentiation | regulation of apoptotic process | gene silencing | regulation of metabolic process | regulation of lung blood pressure | production of miRNAs involved in gene silencing by miRNA | regulation of cytosolic calcium ion concentration | hepaticobiliary system development | positive regulation of extracellular matrix organization | transdifferentiation | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | epithelium development | cellular aromatic compound metabolic process | cellular component organization | protein deubiquitination | calcium ion homeostasis | response to transforming growth factor beta | urogenital system development | T cell activation | thyroid gland development | response to stimulus | positive regulation of interleukin-1 beta production | regulation of cellular protein localization | paraxial mesoderm development | positive regulation of nitric oxide metabolic process | positive regulation of protein metabolic process | positive regulation of peptidase activity | determination of heart left/right asymmetry | mesoderm formation | response to stress | positive regulation of cellular protein localization | cellular nitrogen compound biosynthetic process | posttranscriptional regulation of gene expression | regulation of cell proliferation | activin receptor signaling pathway | positive regulation of actin filament bundle assembly | tube morphogenesis | positive regulation of cysteine-type endopeptidase activity | ncRNA processing | programmed cell death | positive regulation of phosphatase activity | embryonic skeletal system development | positive regulation of proteolysis | cellular nitrogen compound metabolic process | cellular response to organic cyclic compound | positive regulation of extracellular matrix assembly | regulation of protein transport | negative regulation of lung blood pressure | activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway | blood circulation | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | cellular component assembly | regulation of wound healing | protein modification process | pericardium development | regulation of peptide transport | regulation of cell adhesion | cellular biosynthetic process | kidney development | embryo development | macromolecule modification | negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | cell-cell signaling | positive regulation of cell-matrix adhesion | regulation of intracellular transport | cell surface receptor signaling pathway involved in cell-cell signaling | metal ion homeostasis | positive regulation of stress fiber assembly | anterior/posterior pattern specification | primary miRNA processing | regulation of nucleic acid-templated transcription | negative regulation of cellular response to transforming growth factor beta stimulus | regulation of neurotransmitter levels | response to nitrogen compound | negative regulation of osteoblast differentiation | apoptotic process | positive regulation of reactive oxygen species biosynthetic process | positive regulation of cell junction assembly | response to external biotic stimulus | system development | response to oxygen levels | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of organelle organization | ureteric bud development | Wnt signaling pathway | negative regulation of growth | regulation of protein stability | regulation of adherens junction organization | regulation of cartilage development | regulation of actin cytoskeleton organization | multicellular organism development | regulation of peptidase activity | regulation of actin filament organization | response to dsRNA | regulation of catalytic activity | regulation of actomyosin structure organization | regulation of ossification | wound healing | determination of bilateral symmetry | regulation of gene expression | positive regulation of chemotaxis | kidney epithelium development | cell cycle | regulation of blood pressure | gene silencing by miRNA | positive regulation of intracellular protein transport | modification of morphology or physiology of other organism | embryonic heart tube morphogenesis | positive regulation of cellular metabolic process | cellular ion homeostasis | animal organ morphogenesis | regulation of pri-miRNA transcription by RNA polymerase II | negative regulation of cardiac muscle hypertrophy | liver development | regulation of protein localization to nucleus | regulation of nitrogen compound metabolic process | regulation of cell migration | regulation of cell-substrate adhesion | enzyme linked receptor protein signaling pathway | regulation of cysteine-type endopeptidase activity involved in apoptotic process | negative regulation of cellular response to growth factor stimulus | regulation of cellular component movement | regulation of transcription by RNA polymerase II | positive regulation of hydrolase activity | positive regulation of cell differentiation | positive regulation of cell migration | cellular response to cytokine stimulus | positive regulation of protein localization to nucleus | biosynthetic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | positive regulation of ossification | mesenchyme morphogenesis | mesonephric epithelium development | positive regulation of pri-miRNA transcription by RNA polymerase II | digestive tract development | positive regulation of endopeptidase activity | cellular protein-containing complex assembly | heart looping | regulation of apoptotic signaling pathway | positive regulation of transforming growth factor beta3 production | endocrine system development | mesonephros development | cation homeostasis | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | sensory organ development | negative regulation of response to wounding | regulation of cardiac muscle hypertrophy in response to stress | regulation of interleukin-1 production | chordate embryonic development | posttranscriptional gene silencing | cellular cation homeostasis | cell communication | regulation of cellular metabolic process | transmembrane receptor protein serine/threonine kinase signaling pathway | positive regulation of interleukin-1 production | skeletal system morphogenesis | positive regulation of cytoskeleton organization | regulation of protein metabolic process | positive regulation of signal transduction | heart development | cellular calcium ion homeostasis | cellular response to dsRNA | homeostatic process | positive regulation of establishment of protein localization | regulation of locomotion | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | renal system development | positive regulation of transport | viral process | negative regulation of cell growth | regulation of cellular response to growth factor stimulus | apoptotic signaling pathway | embryonic morphogenesis | regulation of mitotic cell cycle | lymphocyte activation | positive regulation of molecular function | regulation of nucleocytoplasmic transport | cellular response to transforming growth factor beta stimulus | negative regulation of cardiac muscle hypertrophy in response to stress | nodal signaling pathway | embryonic organ morphogenesis | embryonic cranial skeleton morphogenesis | protein-containing complex assembly | positive regulation of transforming growth factor beta production | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | protein metabolic process | regulation of cardiac muscle hypertrophy | DNA-binding transcription factor activity | positive regulation of focal adhesion assembly | regulation of establishment of protein localization | regionalization | negative regulation of transforming growth factor beta receptor signaling pathway | regulation of growth | posttranscriptional gene silencing by RNA | response to organic substance | gland development | SMAD protein complex assembly | tissue morphogenesis | regulation of protein import into nucleus | digestive system development | cell cycle arrest | response to wounding | negative regulation of ossification | regulation of DNA-binding transcription factor activity | regulation of focal adhesion assembly | embryonic heart tube development | anatomical structure development | cell surface receptor signaling pathway | embryonic skeletal system morphogenesis | metabolic process | positive regulation of supramolecular fiber organization | activation of cysteine-type endopeptidase activity involved in apoptotic process | regulation of protein catabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | embryonic organ development | negative regulation of mitotic cell cycle | adrenal gland development | chemical homeostasis | positive regulation of cell death | immune response | regulation of chondrocyte differentiation | nucleobase-containing compound metabolic process | positive regulation of cellular component biogenesis | organic substance metabolic process | cell death | regulation of extracellular matrix assembly | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | positive regulation of cell-substrate adhesion | gene expression | positive regulation of programmed cell death | ion homeostasis | protein modification by small protein conjugation or removal | regulation of Wnt signaling pathway | regulation of phosphate metabolic process | regulation of transforming growth factor beta2 production | negative regulation of cardiac muscle adaptation | transcription, DNA-templated | positive regulation of cytokine production | positive regulation of intracellular transport | cell activation | positive regulation of protein transport | camera-type eye development | regulation of reactive oxygen species biosynthetic process | positive regulation of canonical Wnt signaling pathway | transforming growth factor beta receptor signaling pathway | anatomical structure formation involved in morphogenesis | regulation of stress fiber assembly | negative regulation of cell cycle | negative regulation of protein catabolic process | negative regulation of protein metabolic process | regulation of response to wounding | regulation of cell communication | negative regulation of signal transduction | signaling | somite development | regulation of transcription, DNA-templated | response to organic cyclic compound | cell development | negative regulation of osteoblast proliferation | regulation of epithelial cell proliferation | cellular protein metabolic process | regulation of cytokine production | endoderm development | anatomical structure morphogenesis | regulation of endopeptidase activity | cellular macromolecule biosynthetic process | regulation of actin filament bundle assembly | positive regulation of protein import into nucleus | response to biotic stimulus | negative regulation of cytosolic calcium ion concentration | regulation of developmental process | segmentation | developmental process | positive regulation of protein import | regulation of cell growth | cellular protein modification process | negative regulation of transcription by RNA polymerase II | tube development | regulation of cell junction assembly | regulation of transport | positive regulation of transcription, DNA-templated | modulation by virus of host morphology or physiology | regulation of reactive oxygen species metabolic process | negative regulation of cell proliferation | ncRNA metabolic process | positive regulation of nucleic acid-templated transcription | transcription coregulator activity | cellular metal ion homeostasis | epithelial cell differentiation | formation of primary germ layer | positive regulation of transcription by RNA polymerase II | regulation of epithelial to mesenchymal transition | heterocycle metabolic process | somitogenesis | positive regulation of nitric oxide biosynthetic process | transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding | in utero embryonic development | positive regulation of metabolic process | regulation of actin filament-based process | ossification | osteoblast differentiation | skeletal system development | gastrulation | immune system process | positive regulation of Wnt signaling pathway | embryonic foregut morphogenesis | cellular metabolic process | cellular response to organic substance | regulation of protein localization | regulation of cell death | positive regulation of cell motility | lens fiber cell differentiation | negative regulation of cell death | positive regulation of alkaline phosphatase activity | circulatory system development | regulation of inflammatory response | divalent inorganic cation homeostasis | positive regulation of nucleocytoplasmic transport | negative regulation of cell differentiation | regulation of cellular component organization | positive regulation of bone mineralization | lens development in camera-type eye | positive regulation of apoptotic signaling pathway | regulation of cytoskeleton organization | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | mesonephric tubule development | positive regulation of gene expression | regulation of cell-matrix adhesion | embryonic pattern specification | cellular response to growth factor stimulus | regulation of muscle organ development | macromolecule metabolic process | multicellular organismal process | cell-cell junction organization | positive regulation of positive chemotaxis | regulation of phosphorus metabolic process
GO Cellular Component
nuclear transcription factor complex | organelle inner membrane | chromosome | intracellular membrane-bounded organelle | organelle membrane | nuclear membrane | cell | nuclear lumen | nuclear inner membrane | transcription factor complex | SMAD protein complex | cytoplasm | intracellular organelle | receptor complex | protein-containing complex | endomembrane system | nucleoplasm | plasma membrane | nuclear envelope | chromatin | nuclear chromosome | heteromeric SMAD protein complex | membrane-bounded organelle | nucleus | organelle | cell periphery | membrane-enclosed lumen | nuclear chromatin | cytosol | intracellular | membrane
