QuickView for Smad7 (gene)
- Gene Symbol:
- SMAD7
Homo sapiens - Full name:
- SMAD family member 7
- Synonyms:
- CRCS3, MADH7, MADH8, mothers against decapentaplegic homolog 7, MAD (mothers against decapentaplegic, Drosophila) homolog 7, MAD homolog 8, Mothers against decapentaplegic, drosophila, homolog of, 7, SMAD, mothers against DPP homolog 7, hSMAD7, mothers against DPP homolog 8
- Genomic Location:
- Chr 18: 44700221-44731079
- Description:
-
The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan): -
Predicted Gene Targets for miR-15 , Predicted Gene Targets for miR-181 , Predicted Gene Targets for miR-20 , Predicted Gene Targets for miR-21 , Predicted Gene Targets for miR-216 , Predicted Gene Targets for miR-25 , Predicted Gene Targets for miR-330 , Predicted Gene Targets for miR-503 , Predicted Gene Targets for miR-96 , Predicted Gene Targets for miR-182
- Cytogenetic Map:
-
18q21.1
GO Molecular Function
beta-catenin binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | cation binding | enzyme binding | nucleic acid binding | protein-containing complex binding | transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity | transforming growth factor beta receptor binding | signaling receptor binding | cytokine receptor binding | ubiquitin-like protein ligase binding | collagen binding | activin binding | DNA binding | ion binding | organic cyclic compound binding | type I transforming growth factor beta receptor binding | I-SMAD binding | protein binding | DNA-binding transcription factor activity | ubiquitin protein ligase binding | transforming growth factor beta receptor, cytoplasmic mediator activity | SMAD binding | metal ion binding | heterocyclic compound binding
GO Biological Process
regulation of activin receptor signaling pathway | protein modification by small protein removal | negative regulation of lymphocyte differentiation | RNA metabolic process | negative regulation of leukocyte activation | regulation of T cell mediated immunity | negative regulation of phosphorylation | regulation of muscle system process | ventricular cardiac muscle tissue morphogenesis | positive regulation of macromolecule biosynthetic process | negative regulation of immune system process | response to cytokine | muscle tissue development | proteolysis | protein stabilization | regulation of localization | cellular protein-containing complex localization | regulation of ventricular cardiac muscle cell membrane depolarization | regulation of immune system process | regulation of transforming growth factor beta receptor signaling pathway | negative regulation of BMP signaling pathway | regulation of T-helper 17 type immune response | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | negative regulation of leukocyte cell-cell adhesion | negative regulation of RNA biosynthetic process | regulation of T cell differentiation | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | adherens junction assembly | positive regulation of protein catabolic process | negative regulation of protein phosphorylation | positive regulation of cell adhesion | blood vessel morphogenesis | positive regulation of cellular biosynthetic process | cellular process | regulation of cell motility | localization | regulation of ubiquitin-protein transferase activity | heart morphogenesis | negative regulation of signaling | negative regulation of peptidyl-serine phosphorylation | negative regulation of nucleic acid-templated transcription | negative regulation of alpha-beta T cell differentiation | macromolecule localization | regulation of proteolysis | negative regulation of T-helper 17 cell differentiation | response to growth factor | positive regulation of nitrogen compound metabolic process | negative regulation of cell migration | pathway-restricted SMAD protein phosphorylation | negative regulation of cellular metabolic process | tissue development | regulation of cell differentiation | negative regulation of CD4-positive, alpha-beta T cell activation | muscle structure development | ventricular septum morphogenesis | cell junction assembly | negative regulation of cell motility | regulation of immune response | regulation of cellular process | regulation of metabolic process | negative regulation of ubiquitin-protein transferase activity | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | epithelium development | cellular aromatic compound metabolic process | cellular component organization | protein deubiquitination | response to transforming growth factor beta | urogenital system development | positive regulation of cellular protein catabolic process | muscle organ morphogenesis | response to stimulus | vasculature development | negative regulation of epithelial to mesenchymal transition | negative regulation of peptidyl-threonine phosphorylation | positive regulation of protein metabolic process | regulation of cellular protein catabolic process | negative regulation of cell adhesion | regulation of CD4-positive, alpha-beta T cell activation | response to stress | negative regulation of lymphocyte activation | cellular nitrogen compound biosynthetic process | regulation of protein ubiquitination | response to laminar fluid shear stress | tube morphogenesis | regulation of blood circulation | cardiac muscle tissue development | positive regulation of cell-cell adhesion | muscle tissue morphogenesis | positive regulation of proteolysis involved in cellular protein catabolic process | cellular localization | cardiovascular system development | cardiac ventricle morphogenesis | positive regulation of proteolysis | cellular nitrogen compound metabolic process | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | cellular component assembly | negative regulation of hemopoiesis | protein modification process | regulation of cell adhesion | cellular biosynthetic process | kidney development | macromolecule modification | negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | regulation of lymphocyte differentiation | blood vessel development | negative regulation of adaptive immune response | regulation of nucleic acid-templated transcription | negative regulation of cellular response to transforming growth factor beta stimulus | regulation of membrane potential | response to BMP | system development | nitrogen compound metabolic process | regulation of signal transduction | ureteric bud development | negative regulation of T-helper cell differentiation | regulation of protein stability | negative regulation of phosphate metabolic process | adherens junction organization | multicellular organism development | negative regulation of catalytic activity | regulation of BMP signaling pathway | phosphorus metabolic process | regulation of muscle contraction | regulation of catalytic activity | regulation of phosphorylation | regulation of CD4-positive, alpha-beta T cell differentiation | regulation of T cell activation | artery development | regulation of gene expression | kidney epithelium development | negative regulation of T-helper 17 type immune response | regulation of membrane depolarization | negative regulation of cytokine production | positive regulation of cellular metabolic process | regulation of lymphocyte activation | animal organ morphogenesis | regulation of nitrogen compound metabolic process | negative regulation of T cell activation | regulation of cell migration | enzyme linked receptor protein signaling pathway | negative regulation of cellular response to growth factor stimulus | negative regulation of DNA-binding transcription factor activity | regulation of cellular component movement | regulation of transcription by RNA polymerase II | regulation of T-helper 17 cell differentiation | regulation of T cell cytokine production | cellular response to cytokine stimulus | biosynthetic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | positive regulation of proteasomal protein catabolic process | negative regulation of immune response | phosphorylation | mesonephric epithelium development | cardiac septum morphogenesis | regulation of heart contraction | protein phosphorylation | mesonephros development | phosphate-containing compound metabolic process | regulation of striated muscle contraction | negative regulation of cell-cell adhesion | striated muscle tissue development | cardiac muscle tissue morphogenesis | cell communication | regulation of cellular metabolic process | transmembrane receptor protein serine/threonine kinase signaling pathway | regulation of alpha-beta T cell differentiation | negative regulation of cell activation | protein-containing complex localization | regulation of cardiac muscle contraction | regulation of cytokine production involved in immune response | regulation of protein metabolic process | heart development | homeostatic process | regulation of protein phosphorylation | negative regulation of CD4-positive, alpha-beta T cell differentiation | regulation of locomotion | regulation of RNA metabolic process | negative regulation of protein ubiquitination | renal system development | regulation of cellular response to growth factor stimulus | negative regulation of T cell differentiation | regulation of proteasomal ubiquitin-dependent protein catabolic process | cellular response to transforming growth factor beta stimulus | ventricular septum development | protein metabolic process | DNA-binding transcription factor activity | cardiac ventricle development | negative regulation of transforming growth factor beta receptor signaling pathway | positive regulation of protein modification process | response to organic substance | tissue morphogenesis | artery morphogenesis | regulation of hemopoiesis | negative regulation of pathway-restricted SMAD protein phosphorylation | regulation of DNA-binding transcription factor activity | ventricular cardiac muscle tissue development | anatomical structure development | cell surface receptor signaling pathway | metabolic process | positive regulation of ubiquitin-dependent protein catabolic process | regulation of protein catabolic process | regulation of adaptive immune response | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | regulation of proteasomal protein catabolic process | cellular protein localization | chemical homeostasis | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | negative regulation of cellular protein metabolic process | gene expression | regulation of cell activation | negative regulation of cellular component movement | ion homeostasis | protein modification by small protein conjugation or removal | regulation of phosphate metabolic process | negative regulation of T cell mediated immunity | transcription, DNA-templated | regulation of peptidyl-serine phosphorylation | transforming growth factor beta receptor signaling pathway | regulation of T-helper cell differentiation | negative regulation of protein metabolic process | BMP signaling pathway | response to fluid shear stress | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | cellular response to leukemia inhibitory factor | signaling | regulation of transcription, DNA-templated | protein localization | cellular protein metabolic process | regulation of cytokine production | anatomical structure morphogenesis | cellular macromolecule localization | cellular macromolecule biosynthetic process | negative regulation of transcription by competitive promoter binding | regulation of developmental process | developmental process | cardiac septum development | cellular protein modification process | negative regulation of alpha-beta T cell activation | negative regulation of transcription by RNA polymerase II | tube development | positive regulation of transcription, DNA-templated | regulation of cell-cell adhesion | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | regulation of epithelial to mesenchymal transition | cardiac chamber development | heterocycle metabolic process | positive regulation of metabolic process | cellular response to BMP stimulus | cellular metabolic process | cellular response to organic substance | circulatory system development | regulation of ubiquitin-dependent protein catabolic process | negative regulation of locomotion | positive regulation of protein ubiquitination | negative regulation of cell differentiation | negative regulation of T cell cytokine production | muscle organ development | signal transduction | regulation of signaling | mesonephric tubule development | regulation of pathway-restricted SMAD protein phosphorylation | positive regulation of gene expression | cellular response to growth factor stimulus | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | extrinsic component of membrane | catenin complex | adherens junction | microtubule organizing center | fibrillar center | cell | nuclear lumen | plasma membrane protein complex | extrinsic component of plasma membrane | transcription factor complex | nucleolus | cytoplasm | intracellular organelle | cell-cell adherens junction | centrosome | cell-cell junction | protein-containing complex | nucleoplasm | plasma membrane | microtubule cytoskeleton | membrane-bounded organelle | nucleus | organelle | cell periphery | membrane-enclosed lumen | cytosol | cytoskeleton | intracellular | cell junction | membrane
