QuickView for Smcx (gene)
- Gene Symbol:
- KDM5C
Homo sapiens - Full name:
- lysine demethylase 5C
- Synonyms:
- DXS1272E, JARID1C, MRX13, MRXJ, MRXSCJ, MRXSJ, SMCX, XE169, lysine-specific demethylase 5C, JmjC domain-containing protein SMCX, Jumonji, AT rich interactive domain 1C (RBP2-like), Jumonji/ARID domain-containing protein 1C, Smcx homolog, X chromosome, Smcy homolog, X-linked, histone demethylase JARID1C, lysine (K)-specific demethylase 5C
- Genomic Location:
- Chr X: 53237378-53271329
- Description:
-
This gene is a member of the SMCY homolog family and encodes a protein with one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers. The DNA-binding motifs suggest this protein is involved in the regulation of transcription and chromatin remodeling. Mutations in this gene have been associated with X-linked cognitive disabili...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Bos taurus , Canis lupus familiaris , Danio rerio , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
Xp11.22
GO Molecular Function
RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | cation binding | nucleic acid binding | demethylase activity | histone demethylase activity (H3-trimethyl-K4 specific) | methylated histone binding | catalytic activity | chromatin binding | modification-dependent protein binding | DNA binding | histone demethylase activity (H3-K4 specific) | histone demethylase activity | ion binding | organic cyclic compound binding | protein binding | zinc ion binding | DNA-binding transcription factor activity | dioxygenase activity | histone binding | transition metal ion binding | metal ion binding | heterocyclic compound binding | oxidoreductase activity
GO Biological Process
RNA metabolic process | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | negative regulation of RNA biosynthetic process | histone modification | cellular process | chromatin organization | protein demethylation | negative regulation of nucleic acid-templated transcription | negative regulation of cellular metabolic process | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular component organization | demethylase activity | cellular nitrogen compound biosynthetic process | histone demethylase activity (H3-trimethyl-K4 specific) | rhythmic process | cellular nitrogen compound metabolic process | negative regulation of metabolic process | protein modification process | cellular biosynthetic process | macromolecule modification | regulation of nucleic acid-templated transcription | nitrogen compound metabolic process | regulation of gene expression | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | histone demethylase activity (H3-K4 specific) | histone demethylase activity | biosynthetic process | aromatic compound biosynthetic process | regulation of cellular metabolic process | regulation of RNA metabolic process | histone demethylation | protein metabolic process | DNA-binding transcription factor activity | metabolic process | regulation of RNA biosynthetic process | histone H3-K4 demethylation | oxidation-reduction process | negative regulation of transcription, DNA-templated | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | gene expression | dioxygenase activity | transcription, DNA-templated | histone H3-K4 demethylation, trimethyl-H3-K4-specific | covalent chromatin modification | regulation of transcription, DNA-templated | cellular protein metabolic process | cellular macromolecule biosynthetic process | histone lysine demethylation | organelle organization | cellular protein modification process | negative regulation of transcription by RNA polymerase II | heterocycle metabolic process | demethylation | chromosome organization | cellular metabolic process | oxidoreductase activity | macromolecule metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | catalytic complex | cell | nuclear lumen | cytoplasm | intracellular organelle | histone methyltransferase complex | protein-containing complex | methyltransferase complex | nucleoplasm | transferase complex | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cytosol | intracellular
